Yeast as a model system to study RecQ helicase function

被引：47

作者：

Ashton, Thomas M. ^{[1
]}

Hickson, Ian D. ^{[1
]}

机构：

[1] Univ Oxford, John Radcliffe Hosp, Weatherall Inst Mol Med, Oxford OX3 9DS, England

来源：

DNA REPAIR | 2010年 / 9卷 / 03期

关键词：

Homologous recombination; Sgs1; Rqh1; Bloom's syndrome; DOUBLE-STRAND BREAK; HOLLIDAY JUNCTION RESOLVASE; TOPOISOMERASE-III-ALPHA; BLOOMS-SYNDROME HELICASE; SGS1 DNA HELICASE; HOMOLOGOUS RECOMBINATION REPAIR; STRUCTURE-SPECIFIC ENDONUCLEASE; CELLS LACKING TELOMERASE; WERNERS-SYNDROME GENES; MEIOTIC CROSSING-OVER;

D O I：

10.1016/j.dnarep.2009.12.007

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Mutations in the highly conserved RecQ helicase, BLM, cause the rare cancer predisposition disorder, Bloom's syndrome. The orthologues of BLM in Saccharomyces cerevisiae and Schizosaccharomyces pombe are SGS1 and rqh1(+), respectively. Studies in these yeast species have revealed a plethora of roles for the Sgs1 and Rqhl proteins in repair of double strand breaks, restart of stalled replication forks, processing of aberrant intermediates that arise during meiotic recombination, and maintenance of telomeres. In this review, we focus on the known roles of Sgs1 and Rqh1 and how studies in yeast species have improved our knowledge of how BLM suppresses neoplastic transformation. C 2009 Elsevier B.V. All rights reserved.

引用

页码：303 / 314

页数：12

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