Direct demonstration of reduction of the output of the human motor cortex induced by a fatiguing muscle contraction

被引：46

作者：

Di Lazzaro, V

Oliviero, A

Tonali, PA

Mazzone, P

Insola, A

Pilato, F

Saturno, E

Dileone, M

Rothwell, JC

机构：

[1] Univ Cattolica Sacro Cuore, Inst Neurol, I-00168 Rome, Italy

[2] Inst Neurol, Sobell Dept Neurophysiol, London WC1N 3BG, England

[3] UCL Natl Hosp Neurol & Neurosurg, London WC1N 3BG, England

[4] Neurophysiol CTO, I-00145 Rome, Italy

[5] Neurosurg CTO, I-00145 Rome, Italy

来源：

EXPERIMENTAL BRAIN RESEARCH | 2003年 / 149卷 / 04期

关键词：

direct demonstration; human motor cortex; fatiguing muscle contraction; EMG response; transcranial magnetic stimulation; descending motor volley;

D O I：

10.1007/s00221-003-1408-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A brief period of strong muscle contraction suppresses the amplitude of EMG responses evoked in relaxed muscle by transcranial magnetic stimulation (TMS) of the contralateral motor cortex. Here we investigate this phenomenon in more detail by recording the descending motor volleys evoked by TMS from electrodes in the cervical epidural space of three conscious patients implanted with chronic electrical stimulators for control of pain. We confirm that fatigue suppresses I waves evoked by TMS. In addition, D waves were suppressed in two of the patients, suggesting that axonal excitability might also be compromised by a period of intense muscle contraction.

引用

页码：535 / 538

页数：4

共 24 条

[21] Motor cortex fatigue in sports measured by transcranial magnetic double stimulation [J].