Cervical root repair in adult rats after transection: recovery of forelimb motor function

被引：20

作者：

Huang, MC

Chen, KC

Chuang, TY

Chang, WC

Lee, LS

Huang, WC

Cheng, H

机构：

[1] Taipei Vet Gen Hosp, Neurol Inst, Dept Neurosurg, Neural Regenerat lab, Taipei 11217, Taiwan

[2] Natl Yang Ming Univ, Sch Med, Taipei 112, Taiwan

[3] Taipei Med Univ, Sch Med, Taipei, Taiwan

[4] Natl Yang Ming Univ, Inst Anat & Cell Biol, Taipei 112, Taiwan

[5] Taipei Vet Gen Hosp, Dept Rehabil Med, Taipei 11217, Taiwan

来源：

EXPERIMENTAL NEUROLOGY | 2003年 / 180卷 / 02期

关键词：

regeneration; aFGF; fibrin glue; cervical root; electromyography; horseradish peroxidase retrograde axonal tracing;

D O I：

10.1016/S0014-4886(02)00026-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Functional recovery was achieved in rats after repairing the transected left sixth and seventh cervical roots. Intercostal nerves were used for reanastomosis between the transected roots and the spinal cord, and acidic fibroblast growth factor with fibrin glue was applied. Experimental rats showed relevant functional recovery of gait and grooming reflexes. Electromyography demonstrated less denervation and more regeneration. Horseradish peroxidase retrograde axonal tracing disclosed a statistically significant increase of motor neuron survival, suggesting that motor neuron survival was significantly correlated with functional recovery. It is our belief that this novel treatment strategy may help patients with similar injuries in the future. (C) 2003 Elsevier Science (USA). All rights reserved.

引用

页码：101 / 109

页数：9

共 33 条

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