Conjugation of amino acid O-methyl esters with AZT-5′-O-phosphorothioate and phosphorodithioate

被引：18

作者：

Baraniak, J ^{[1
]}

Kaczmarek, R ^{[1
]}

Stec, WJ ^{[1
]}

机构：

[1] Polish Acad Sci, Ctr Mol & Macromol Studies, Dept Bioorgan Chem, PL-90363 Lodz, Poland

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 47期

关键词：

AZT; N-phosphorothioylated amino acid; oxathia(-dithia)phospholane ring-opening condensation;

D O I：

10.1016/S0040-4039(00)01635-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Based upon 1,3,2-oxathia(-dithia)phospholane chemistry, 5'-O-derivatisation of AZT with the O-methyl esters of L-phenylalanine and L-tryptophan was performed and the corresponding 5'-aminoacidophosphoramidothioates or phosphoramidodithioates of AZT were obtained in satisfactory yield. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：9139 / 9142

页数：4

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