α-klotho as a regulator of calcium homeostasis

被引：327

作者：

Imura, Akihiro

Tsuji, Yoshihito

Murata, Miyahiko

Maeda, Ryota

Kubota, Koji

Iwano, Akiko

Obuse, Chikashi

Togashi, Kazuya

Tominaga, Makoto

Kita, Naoko

Tomiyama, Ken-ichi

Iijima, Junko

Nabeshima, Yoko

Fujioka, Makio

Asato, Ryo

Tanaka, Shinzo

Kojima, Ken

Ito, Juichi

Nozaki, Kazuhiko

Hashimoto, Nobuo

Ito, Tetsufumi

Nishio, Takeshi

Uchiyama, Takashi

Fujimori, Toshihiko

Nabeshima, Yo-ichi ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Med, Dept Pathol & Tumor Biol, Kyoto 6068501, Japan

[2] Kyoto Univ, Grad Sch Med, Horizontal Med Res Org, Kyoto 6068501, Japan

[3] Kyoto Univ, Grad Sch Med, Dept Otolaryngol Head & Neck Surg, Kyoto 6068501, Japan

[4] Kyoto Univ, Grad Sch Med, Dept Neurosurg, Kyoto 6068501, Japan

[5] Kyoto Univ, Grad Sch Med, Dept Hematol & Oncol, Kyoto 6068501, Japan

[6] Kyoto Univ, Grad Sch Med, Ctr Electron Microscopy, Kyoto 6068501, Japan

[7] Japan Sci & Technol Corp, Core Res Evolut Sci & Technol, Saitama 3320012, Japan

[8] Hokkaido Univ, Grad Sch Life Sci, Lab Funct Networks Chromosome Inheritance, Sapporo, Hokkaido 0010021, Japan

[9] Natl Inst Nat Sci, Okazaki Inst Integrat Biosci, Sect Cell Signaling, Aichi 4448787, Japan

[10] Univ Fukui, Fac Med Sci, Dept Anat, Fukui 9101193, Japan

来源：

SCIENCE | 2007年 / 316卷 / 5831期

关键词：

D O I：

10.1126/science.1135901

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

alpha-klotho was identified as a gene associated with premature aging-like phenotypes characterized by short lifespan. In mice, we found the molecular association of alpha-Klotho (alpha-Kl) and Na+, K+-adenosine triphosphatase (Na+, K+-ATPase) and provide evidence for an increase of abundance of Na+, K+-ATPase at the plasma membrane. Low concentrations of extracellular free calcium ([Ca2+](e)) rapidly induce regulated parathyroid hormone (PTH) secretion in an alpha-Kl- and Na+, K+-ATPase-dependent manner. The increased Na+ gradient created by Na+, K+-ATPase activity might drive the transepithelial transport of Ca2+ in cooperation with ion channels and transporters in the choroid plexus and the kidney. Our findings reveal fundamental roles of alpha-Kl in the regulation of calcium metabolism.

引用

页码：1615 / 1618

页数：4

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