Microtubule dynamics in living cells

被引:115
作者
Joshi, HC [1 ]
机构
[1] Emory Univ, Sch Med, Dept Cell Biol, Atlanta, GA 30322 USA
基金
美国国家卫生研究院;
关键词
D O I
10.1016/S0955-0674(98)80084-7
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Most people think of a skeleton as a solid and static framework upon which complex structures are elaborated. From what we have learned in the past decade about the cytoskeleton, it seems certain that the 'skeleton' part of the term is a bit misleading. It is clear now that the polymers that constitute the cytoskeleton, actin filaments, microtubules, and intermediate filaments, are all in fact ever-changing dynamic infrastructures of cells. Recently, advances have been made in the study of the cellular dynamics of one of the prominent components of the cytoskeleton, the microtubules. Observations in the past year have revealed some fundamental in vivo behaviors of these polymers, during interphase, during mitosis, and during the elaboration of postmitotic axonal microtubule arrays. These observations are important for the understanding of cytoplasmic organization in many types of cells.
引用
收藏
页码:35 / 44
页数:10
相关论文
共 65 条
[21]   POLARITY OF FLAGELLAR ASSEMBLY IN CHLAMYDOMONAS [J].
JOHNSON, KA ;
ROSENBAUM, JL .
JOURNAL OF CELL BIOLOGY, 1992, 119 (06) :1605-1611
[22]   TENSION AND COMPRESSION IN THE CYTOSKELETON OF PC-12 NEURITES [J].
JOSHI, HC ;
CHU, D ;
BUXBAUM, RE ;
HEIDEMANN, SR .
JOURNAL OF CELL BIOLOGY, 1985, 101 (03) :697-705
[23]   Microtubule release from the centrosome [J].
Keating, TJ ;
Peloquin, JG ;
Rodionov, VI ;
Momcilovic, D ;
Borisy, GG .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (10) :5078-5083
[24]   BEYOND SELF-ASSEMBLY - FROM MICROTUBULES TO MORPHOGENESIS [J].
KIRSCHNER, M ;
MITCHISON, T .
CELL, 1986, 45 (03) :329-342
[25]   OVEREXPRESSION OF TAU IN A NONNEURONAL CELL INDUCES LONG CELLULAR PROCESSES [J].
KNOPS, J ;
KOSIK, KS ;
LEE, G ;
PARDEE, JD ;
COHENGOULD, L ;
MCCONLOGUE, L .
JOURNAL OF CELL BIOLOGY, 1991, 114 (04) :725-733
[26]   TRANSLOCATION OF THE NEURONAL CYTOSKELETON AND AXONAL LOCOMOTION [J].
LASEK, RJ .
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES, 1982, 299 (1095) :313-327
[27]   NEUROFILAMENTS ARE OBLIGATE HETEROPOLYMERS IN-VIVO [J].
LEE, MK ;
XU, ZS ;
WONG, PC ;
CLEVELAND, DW .
JOURNAL OF CELL BIOLOGY, 1993, 122 (06) :1337-1350
[28]   GAMMA-TUBULIN IS A MINUS END-SPECIFIC MICROTUBULE-BINDING PROTEIN [J].
LI, QQ ;
JOSHI, HC .
JOURNAL OF CELL BIOLOGY, 1995, 131 (01) :207-214
[29]   A TEST OF MICROTUBULE TRANSLOCATION DURING NEURITE ELONGATION [J].
LIM, SS ;
EDSON, KJ ;
LETOURNEAU, PC ;
BORISY, GG .
JOURNAL OF CELL BIOLOGY, 1990, 111 (01) :123-130
[30]   INTERPOLAR SPINDLE MICROTUBULES IN PTK CELLS [J].
MASTRONARDE, DN ;
MCDONALD, KL ;
DING, R ;
MCINTOSH, JR .
JOURNAL OF CELL BIOLOGY, 1993, 123 (06) :1475-1489