学术探索
学术期刊
新闻热点
数据分析
智能评审

The ABCs of granule-mediated cytotoxicity: New weapons in the arsenal

被引：511
作者：
Lieberman, J [1 ]
机构：
[1] Harvard Univ, Sch Med, Ctr Blood Res, Boston, MA 02115 USA
[2] Harvard Univ, Sch Med, Dept Pediat, Boston, MA 02115 USA
来源：
NATURE REVIEWS IMMUNOLOGY | 2003年 / 3卷 / 05期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1038/nri1083
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Granule exocytosis is the main pathway for the immune elimination of virus-infected cells and tumour cells by cytotoxic T lymphocytes and natural killer cells. After target-cell recognition, release of the cytotoxic granule contents into the immunological synapse formed between the killer cell and its target induces apoptosis. The granules contain two membrane-perturbing proteins, perforin and granulysin, and a family of serine proteases known as granzymes, complexed with the proteoglycan serglycin. In this review, I discuss recent insights into the mechanisms of granule-mediated cytotoxicity, focusing on how granzymes A, Band C and granulysin activate cell death through caspase-independent pathways.
引用
收藏
页码：361 / 370
页数：10
相关论文
共 106 条
  • [1] Granzyme B induces BID-mediated cytochrome c release and mitochondrial permeability transition
    Alimonti, JB
    Shi, LF
    Baijal, PK
    Greenberg, AH
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (10) : 6974 - 6982
  • [2] Granulysin crystal structure and a structure-derived lytic mechanism
    Anderson, DH
    Sawaya, MR
    Cascio, D
    Ernst, W
    Modlin, R
    Krensky, A
    Eisenberg, D
    [J]. JOURNAL OF MOLECULAR BIOLOGY, 2003, 325 (02) : 355 - 365
  • [3] Granzyme B directly and efficiently cleaves several downstream caspase substrates: Implications for CTL-induced apoptosis
    Andrade, F
    Roy, S
    Nicholson, D
    Thornberry, N
    Rosen, A
    Casciola-Rosen, L
    [J]. IMMUNITY, 1998, 8 (04) : 451 - 460
  • [4] Interaction between a Ca2+-binding protein calreticulin and perforin, a component of the cytotoxic T-Cell granules
    Andrin, C
    Pinkoski, MJ
    Burns, K
    Atkinson, EA
    Krahenbuhl, O
    Hudig, D
    Fraser, SA
    Winkler, U
    Tschopp, J
    Opas, M
    Bleackley, RC
    Michalak, M
    [J]. BIOCHEMISTRY, 1998, 37 (29) : 10386 - 10394
  • [5] Babe LM, 1998, BIOTECHNOL APPL BIOC, V27, P117
  • [6] Surface cathepsin B protects cytotoxic lymphocytes from self-destruction after degranulation
    Balaji, KN
    Schaschke, N
    Machleidt, W
    Catalfamo, M
    Henkart, PA
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 196 (04) : 493 - 503
  • [7] Concerted action of the FasL/Fas and perforin/granzyme A and B pathways is mandatory for the development of early viral hepatitis but not for recovery from viral infection
    Balkow, S
    Kersten, A
    Tran, TTT
    Stehle, T
    Grosse, P
    Museteanu, C
    Utermöhlen, O
    Pircher, H
    von Weizsäcker, F
    Wallich, R
    Müllbacher, A
    Simon, MM
    [J]. JOURNAL OF VIROLOGY, 2001, 75 (18) : 8781 - 8791
  • [8] Granzyme B short-circuits the need for caspase 8 activity during granule-mediated cytotoxic T-lymphocyte killing by directly cleaving bid
    Barry, M
    Heibein, JA
    Pinkoski, MJ
    Lee, SF
    Moyer, RW
    Green, DR
    Bleackley, RC
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 2000, 20 (11) : 3781 - 3794
  • [9] Granzyme A activates an endoplasmic reticulum-associated caspase-independent nuclease to induce single-stranded DNA nicks
    Beresford, PJ
    Zhang, D
    Oh, DY
    Fan, ZS
    Greer, EL
    Russo, ML
    Jaju, M
    Lieberman, J
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (46) : 43285 - 43293
  • [10] Granzyme A loading induces rapid cytolysis and a novel form of DNA damage independently of caspase activation
    Beresford, PJ
    Xia, ZN
    Greenberg, AH
    Lieberman, J
    [J]. IMMUNITY, 1999, 10 (05) : 585 - 594
12345678910