The ABCs of granule-mediated cytotoxicity: New weapons in the arsenal

被引：511

作者：

Lieberman, J ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Ctr Blood Res, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dept Pediat, Boston, MA 02115 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2003年 / 3卷 / 05期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nri1083

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Granule exocytosis is the main pathway for the immune elimination of virus-infected cells and tumour cells by cytotoxic T lymphocytes and natural killer cells. After target-cell recognition, release of the cytotoxic granule contents into the immunological synapse formed between the killer cell and its target induces apoptosis. The granules contain two membrane-perturbing proteins, perforin and granulysin, and a family of serine proteases known as granzymes, complexed with the proteoglycan serglycin. In this review, I discuss recent insights into the mechanisms of granule-mediated cytotoxicity, focusing on how granzymes A, Band C and granulysin activate cell death through caspase-independent pathways.

引用

页码：361 / 370

页数：10

共 106 条

[71] Lymphocyte-mediated cytotoxicity [J].

Russell, JH ;

Ley, TJ .

ANNUAL REVIEW OF IMMUNOLOGY, 2002, 20 :323-370

[72] Target cell lysis by CTL granule exocytosis is independent of ICE/Ced-3 family proteases [J].

Sarin, A ;

Williams, MS ;

AlexanderMiller, MA ;

Berzofsky, JA ;

Zacharchuk, CM ;

Henkart, PA .

IMMUNITY, 1997, 6 (02) :209-215

[73] The restricted expression of granzyme M in human lymphocytes [J].

Sayers, TJ ;

Brooks, AD ;

Ward, JM ;

Hoshino, T ;

Bere, WE ;

Wiegand, GW ;

Kelley, JM ;

Smyth, MJ .

JOURNAL OF IMMUNOLOGY, 2001, 166 (02) :765-771

[74] Regulation of Fas(Apo-1/CD95)- and perforin-mediated lytic pathways of primary cytotoxic T Lymphocytes by the protooncogene bcl-2 [J].

Schroter, M ;

Lowin, B ;

Borner, C ;

Tschopp, J .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1995, 25 (12) :3509-3513

[75] Direct cleavage of the human DNA fragmentation factor-45 by granzyme B induces caspase-activated DNase release and DNA fragmentation [J].

Sharif-Askari, E ;

Alam, A ;

Rhéaume, E ;

Beresford, PJ ;

Scotto, C ;

Sharma, K ;

Lee, D ;

DeWolf, WE ;

Nuttall, ME ;

Lieberman, J ;

Sékaly, RP .

EMBO JOURNAL, 2001, 20 (12) :3101-3113

[76] A NATURAL-KILLER-CELL GRANULE PROTEIN THAT INDUCES DNA FRAGMENTATION AND APOPTOSIS [J].

SHI, LF ;

KRAUT, RP ;

AEBERSOLD, R ;

GREENBERG, AH .

JOURNAL OF EXPERIMENTAL MEDICINE, 1992, 175 (02) :553-566

[77] PURIFICATION OF 3 CYTOTOXIC LYMPHOCYTE GRANULE SERINE PROTEASES THAT INDUCE APOPTOSIS THROUGH DISTINCT SUBSTRATE AND TARGET-CELL INTERACTIONS [J].

SHI, LF ;

KAM, CM ;

POWERS, JC ;

AEBERSOLD, R ;

GREENBERG, AH .

JOURNAL OF EXPERIMENTAL MEDICINE, 1992, 176 (06) :1521-1529

[78] Granzyme B (GraB) autonomously crosses the cell membrane and perforin initiates apoptosis and GraB nuclear localization [J].

Shi, LF ;

Mai, S ;

Israels, S ;

Browne, K ;

Trapani, JA ;

Greenberg, AH .

JOURNAL OF EXPERIMENTAL MEDICINE, 1997, 185 (05) :855-866

[79] Granzyme A initiates an alternative pathway for granule-mediated apoptosis [J].

Shresta, S ;

Graubert, TA ;

Thomas, DA ;

Raptis, SZ ;

Ley, TJ .

IMMUNITY, 1999, 10 (05) :595-605

[80]

SMYTH MJ, 1993, J IMMUNOL, V151, P6195

← 2 3 4 5 6 7 8 9 10 11 →