Effect of omeprazole on the pharmacokinetics of itraconazole

被引：97

作者：

Jaruratanasirikul, S ^{[1
]}

Sriwiriyajan, S ^{[1
]}

机构：

[1] Prince Songkla Univ, Dept Med, Fac Med, Div Clin Pharmacol, Hat Yai 90112, Songkla, Thailand

来源：

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY | 1998年 / 54卷 / 02期

关键词：

omeprazole; itraconazole;

D O I：

10.1007/s002280050438

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Objective: To investigate the effect of omeprazole on the pharmacokinetics of itraconazole. Methods: Eleven healthy volunteers received a single dose of oral itraconazole (200 mg) on days 1 and 15 and oral omeprazole (40 mg) once daily from day 2 to day 15. Itraconazole pharmacokinetics were studied on days 1 and 15. Results: Concentrations of itraconazole were higher when it was taken alone than when it was taken with omeprazole. With concomitant omeprazole treatment, the mean AUC(0-24) and C-max of itraconazole were significantly reduced by 64% and 66%, respectively. Conclusion: Omeprazole affects itraconazole kinetics, leading to a reduction in bioavailability and C-max. These two drugs should not be used together.

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收藏

页码：159 / 161

页数：3

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