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The interplay between inflammation and neurodegeneration in CNS disease

被引：63
作者：
Esiri, Margaret M. [1 ]
机构：
[1] Univ Oxford, Dept Clin Neurol, Oxford, England
[2] Oxford Radcliffe NHS Trust, Dept Neuropathol, Oxford, England
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2007年 / 184卷 / 1-2期
关键词：
inflammation; CNS diseases; neurodegeneration; neuroprotection; microglia; neuropathology;
D O I：
10.1016/j.jneuroim.2006.11.013
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
This review considers the manner in which inflammation in the CNS contributes to, and protects against, neurodegeneration. A series of questions are posed, first about primarily inflammatory diseases and the causes of neurodegeneration that occurs in them, and then about neurodegenerative diseases and stroke and the role that inflammation plays there. Common themes as well as disease-specific differences are highlighted in this survey of the recent human disease and animal model literature. (c) 2006 Elsevier B.V. All rights reserved.
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页码：4 / 16
页数：13
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