Lymphocytes with a complex: adapter proteins in antigen receptor signaling

被引：100

作者：

Tomlinson, MG ^{[1
]}

Lin, J

Weiss, A

机构：

[1] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Howard Hughes Med Inst, San Francisco, CA 94143 USA

来源：

IMMUNOLOGY TODAY | 2000年 / 21卷 / 11期

关键词：

D O I：

10.1016/S0167-5699(00)01716-3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Adapters can be defined as proteins that mediate intermolecular interactions within a signal transduction pathway and that lack both intrinsic enzymatic and transcriptional activity. Their essential role in lymphocyte signaling was revealed by recent analyses of mice and cell lines deficient in LAT, SLP-76 and BLNK. These and other adapters nucleate signaling complexes and facilitate coupling of antigen receptor triggering to functional responses in lymphocytes.

引用

页码：584 / 591

页数：8

共 65 条

[61] Uncoupling of nonreceptor tyrosine kinases from PLC-γ1 in an SLP-76-deficient T cell [J].

Yablonski, D ;

Kuhne, MR ;

Kadlecek, T ;

Weiss, A .

SCIENCE, 1998, 281 (5375) :413-416

[62]

Yamanashi Y, 2000, GENE DEV, V14, P11

[63] Cbl suppresses B cell receptor-mediated phospholipase C (PLC)-γ2 activation by regulating B cell linker protein-PLC-γ2 binding [J].

Yasuda, T ;

Maeda, A ;

Kurosaki, M ;

Tezuka, T ;

Hironaka, K ;

Yamamoto, T ;

Kurosaki, T .

JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 191 (04) :641-650

[64] Association of Grb2 Gads, and phospholipase C-γ1 with phosphorylated LAT tyrosine residues -: Effect of LAT tyrosine mutations on T cell antigen receptor-mediated signaling [J].

Zhang, WG ;

Trible, RP ;

Zhu, MH ;

Liu, SK ;

McGlade, J ;

Samelson, LE .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (30) :23355-23361

[65] The role of membrane-associated adaptors in T cell receptor signalling [J].

Zhang, WG ;

Samelson, LE .

SEMINARS IN IMMUNOLOGY, 2000, 12 (01) :35-41

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