The pharmacophore of short cationic antibacterial peptides

被引：280

作者：

Strom, MB ^{[1
]}

Haug, BE ^{[1
]}

Skar, ML ^{[1
]}

Stensen, W ^{[1
]}

Stiberg, T ^{[1
]}

Svendsen, JS ^{[1
]}

机构：

[1] Univ Tromso, Dept Chem, N-9037 Tromso, Norway

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2003年 / 46卷 / 09期

关键词：

D O I：

10.1021/jm0340039

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Cationic antibacterial peptides have been proclaimed as new drugs against multiresistant bacteria. Their limited success so far is partially due to the size of the peptides, which gives rise to unresolved issues regarding administration, bioavailability, metabolic stability, and immunogenicity. We have systematically investigated the minimum antibacterial motif of cationic antibacterial peptides regarding charge and lipophilicity/bulk and found that the pharmacophore was surprisingly small, opening the opportunity for development of short antibacterial peptides for systemic use.

引用

页码：1567 / 1570

页数：4

共 19 条

[11] De novo design, synthesis, and characterization of antimicrobial β-peptides [J].