Efficient revascularization by VEGF administration via heparin-functionalized nanoparticle-fibrin complex

被引：74

作者：

Chung, Yong-Il ^{[1
]}

Kim, Sang-Ki ^{[3
,4
]}

Lee, Youn-Kyung ^{[5
]}

Park, Su-Jin ^{[6
,7
]}

Cho, Kyoung-Oh ^{[8
]}

Yuk, Soon Hong ^{[9
]}

Tae, Giyoong ^{[1
,2
]}

Kim, Young Ha ^{[1
,2
]}

机构：

[1] Gwangju Inst Sci & Technol, Dept Mat Sci & Engn, Kwangju 500712, South Korea

[2] Gwangju Inst Sci & Technol, Dept Nanobio Mat & Elect, Kwangju 500712, South Korea

[3] Kongju Natl Univ, Dept Compan, Yesan 340702, South Korea

[4] Kongju Natl Univ, Lab Anim Sci, Yesan 340702, South Korea

[5] Chonnam Natl Univ, Hwasun Hosp, Res Ctr Canc Immunotherapy, Jeonnam 519809, South Korea

[6] Korea Res Inst Biosci & Biotechnol, Ecofriendly Biomat Res Ctr, Jeongeup 580185, South Korea

[7] Korea Res Inst Biosci & Biotechnol, AI Control Mat Res Ctr, Jeongeup 580185, South Korea

[8] Chonnam Natl Univ, Coll Vet Med, Kwangju 500757, South Korea

[9] Hannam Univ, Dept Adv Mat, Taejon 305811, South Korea

来源：

JOURNAL OF CONTROLLED RELEASE | 2010年 / 143卷 / 03期

关键词：

Angiogenesis; Growth factors; Controlled release; Heparin; Fibrin; ENDOTHELIAL GROWTH-FACTOR; VASCULAR-PERMEABILITY FACTOR; CONTROLLED-RELEASE; ANGIOGENESIS; CELL; MIGRATION; STABILIZATION; DEGRADATION; MECHANISMS; HYDROGELS;

D O I：

10.1016/j.jconrel.2010.01.010

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

We investigated the angiogenic bioactivity and therapeutic angiogenic effect of vascular endothelial growth factor (VEGF) administration by the heparin-functionalized nanoparticle-fibrin gel complex. The markedly increased bioactivity was observed by the VEGF-loaded nanoparticle-fibrin gel complex, compared to the VEGF-loaded fibrin gel, the nanoparticle-fibrin gel complex without VEGF, or fibrin gel (control) in terms of the capillary density in a mouse subcutaneous implantation model. Furthermore, the VEGF-loaded nanoparticle-fibrin gel complex significantly enhanced the therapeutic angiogenic effect in a rabbit ischemic hind limb model: the noticeable increase in the recovered calf blood pressure, the angiographic score, and the density of collaterals, as well as the stable maintenance of the organized collaterals, compared to the VEGF-loaded fibrin gel. These results show the enhanced angiogenic potential of VEGF administration by the proposed heparin-functionalized nanoparticle-fibrin gel complex. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：282 / 289

页数：8

共 30 条

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