Human mitochondrial mTERF wraps around DNA through a left-handed superhelical tandem repeat

被引：34

作者：

Jimenez-Menendez, Nereida ^{[1
,2
]}

Fernandez-Millan, Pablo ^{[1
]}

Rubio-Cosials, Anna ^{[1
]}

Arnan, Carme ^{[1
,2
]}

Montoya, Julio ^{[3
]}

Jacobs, Howard T. ^{[4
,5
]}

Bernado, Pau ^{[2
]}

Coll, Miquel ^{[1
,2
]}

Uson, Isabel ^{[1
,6
]}

Sola, Maria ^{[1
]}

机构：

[1] Inst Biol Mol Barcelona, Barcelona, Spain

[2] Inst Res Biomed, Barcelona, Spain

[3] Univ Zaragoza, CIBER Enfermedades Raras, Dept Bioquim & Biol Mol & Celular, Zaragoza, Spain

[4] Univ Tampere, Inst Med Technol, FIN-33101 Tampere, Finland

[5] Univ Tampere, Tampere Univ Hosp, FIN-33101 Tampere, Finland

[6] Inst Catalana Recerca & Estudis Avancats, Barcelona, Spain

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2010年 / 17卷 / 07期

基金：

芬兰科学院;

关键词：

TERMINATION FACTOR MTERF; STRUCTURAL-ANALYSIS; TRANSCRIPTION; RNA; RECOGNITION; PROTEIN; COMPLEX; BINDING; FAMILY;

D O I：

10.1038/nsmb.1859

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The regulation of mitochondrial DNA (mtDNA) processes is slowly being characterized at a structural level. We present here crystal structures of human mitochondrial regulator mTERF, a transcription termination factor also implicated in replication pausing, in complex with double-stranded DNA oligonucleotides containing the tRNA(UUR)(Leu) gene sequence. mTERF comprises nine left-handed helical tandem repeats that form a left-handed superhelix, the Zurdo domain.

引用

页码：891 / 893

页数：3

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