Epigenetic phase variation of the pap operon in Escherichia coli

被引：130

作者：

vanderWoude, M ^{[1
]}

Braaten, B ^{[1
]}

Low, D ^{[1
]}

机构：

[1] UNIV UTAH, HLTH SCI CTR, DEPT PATHOL, DIV CELL BIOL & IMMUNOL, SALT LAKE CITY, UT 84132 USA

来源：

TRENDS IN MICROBIOLOGY | 1996年 / 4卷 / 01期

关键词：

D O I：

10.1016/0966-842X(96)81498-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Expression of the pyelonephritis-associated pilus (pap) operon in Escherichia coli is regulated by a complex epigenetic phase-variation mechanism involving the formation of differential DNA-methylation patterns. This review discusses how DNA-methylation patterns are formed by protein-DNA interactions and how methylation patterns, in turn, control pap gene expression.

引用

页码：5 / 9

页数：5

共 39 条

[1] TRANSCRIPTIONAL ACTIVATION OF A PAP PILUS VIRULENCE OPERON FROM UROPATHOGENIC ESCHERICHIA-COLI [J].

BAGA, M ;

GORANSSON, M ;

NORMARK, S ;

UHLIN, BE .

EMBO JOURNAL, 1985, 4 (13B) :3887-3893

[2] PROCESSED MESSENGER-RNA WITH DIFFERENTIAL STABILITY IN THE REGULATION OF ESCHERICHIA-COLI PILIN GENE-EXPRESSION [J].

BAGA, M ;

GORANSSON, M ;

NORMARK, S ;

UHLIN, BE .

CELL, 1988, 52 (02) :197-206

[3] TRANSCRIPTIONAL ORGANIZATION OF THE F1845 FIMBRIAL ADHESIN DETERMINANT OF ESCHERICHIA-COLI [J].

BILGE, SS ;

APOSTOL, JM ;

FULLNER, KJ ;

MOSELEY, SL .

MOLECULAR MICROBIOLOGY, 1993, 7 (06) :993-1006

[4] PHASE-VARIATION OF PYELONEPHRITIS-ASSOCIATED PILI IN ESCHERICHIA-COLI - EVIDENCE FOR TRANSCRIPTIONAL REGULATION [J].

BLYN, LB ;

BRAATEN, BA ;

WHITEZIEGLER, CA ;

ROLFSON, DH ;

LOW, DA .

EMBO JOURNAL, 1989, 8 (02) :613-620

[5] REGULATION OF PAP PILIN PHASE VARIATION BY A MECHANISM INVOLVING DIFFERENTIAL DAM METHYLATION STATES [J].

BLYN, LB ;

BRAATEN, BA ;

LOW, DA .

EMBO JOURNAL, 1990, 9 (12) :4045-4054

[6] QUANTITATION OF DAM METHYLTRANSFERASE IN ESCHERICHIA-COLI [J].

BOYE, E ;

MARINUS, MG ;

LOBNEROLESEN, A .

JOURNAL OF BACTERIOLOGY, 1992, 174 (05) :1682-1685

[7] METHYLATION PATTERNS IN PAP REGULATORY DNA CONTROL PYELONEPHRITIS-ASSOCIATED PILI PHASE VARIATION IN ESCHERICHIA-COLI [J].

BRAATEN, BA ;

NOU, XW ;

KALTENBACH, LS ;

LOW, DA .

CELL, 1994, 76 (03) :577-588

[8] EVIDENCE FOR A METHYLATION-BLOCKING FACTOR (MBF) LOCUS INVOLVED IN PAP PILUS EXPRESSION AND PHASE VARIATION IN ESCHERICHIA-COLI [J].

BRAATEN, BA ;

BLYN, LB ;

SKINNER, BS ;

LOW, DA .

JOURNAL OF BACTERIOLOGY, 1991, 173 (05) :1789-1800

[9] THE LEUCINE-RESPONSIVE REGULATORY PROTEIN, A GLOBAL REGULATOR OF METABOLISM IN ESCHERICHIA-COLI [J].

CALVO, JM ;

MATTHEWS, RG .

MICROBIOLOGICAL REVIEWS, 1994, 58 (03) :466-490

[10]

DIRITA VJ, 1989, ANNU REV GENET, V23, P455

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