Epigenetic phase variation of the pap operon in Escherichia coli

被引：130

作者：

vanderWoude, M ^{[1
]}

Braaten, B ^{[1
]}

Low, D ^{[1
]}

机构：

[1] UNIV UTAH, HLTH SCI CTR, DEPT PATHOL, DIV CELL BIOL & IMMUNOL, SALT LAKE CITY, UT 84132 USA

来源：

TRENDS IN MICROBIOLOGY | 1996年 / 4卷 / 01期

关键词：

D O I：

10.1016/0966-842X(96)81498-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Expression of the pyelonephritis-associated pilus (pap) operon in Escherichia coli is regulated by a complex epigenetic phase-variation mechanism involving the formation of differential DNA-methylation patterns. This review discusses how DNA-methylation patterns are formed by protein-DNA interactions and how methylation patterns, in turn, control pap gene expression.

引用

页码：5 / 9

页数：5

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