The transforming growth factor-βs:: Structure, signaling, and roles in nervous system development and functions

被引：254

作者：

Böttner, M

Krieglstein, K

Unsicker, K

机构：

[1] Heidelberg Univ, Ctr Neurosci, D-69120 Heidelberg, Germany

[2] Univ Saarland, Homburg, Germany

来源：

JOURNAL OF NEUROCHEMISTRY | 2000年 / 75卷 / 06期

关键词：

growth factors; neuron death; glia differentiation; cell lineage; repair;

D O I：

10.1046/j.1471-4159.2000.0752227.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Transforming growth factor-betas (TGF-betas) are among the most widespread and versatile cytokines. Here, we first provide a brief overview of their molecular biology, biochemistry, and signaling. We then review distribution and functions of the three mammalian TGF-beta isoforms, beta1, beta2, and beta3, and their receptors in the developing and adult nervous system. Roles of TGF-betas in the regulation of radial glia, astroglia, oligodendroglia, and microglia are addressed. Finally, we review the current state of knowledge concerning the roles of TGF-betas in controlling neuronal performances, including the regulation of proliferation of neuronal precursors, survival/death decisions, and neuronal differentiation.

引用

收藏

页码：2227 / 2240

页数：14

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