Not a split decision for human hematopoiesis

被引：7

作者：

Dorshkind, Kenneth ^{[1
]}

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA

来源：

NATURE IMMUNOLOGY | 2010年 / 11卷 / 07期

关键词：

STEM-CELLS; LINEAGE COMMITMENT; LYMPHOID-CELLS; PROGENITORS; IDENTIFICATION; SYSTEM; GENE; MICE;

D O I：

10.1038/ni0710-569

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Hematopoietic lineage schemes commonly show two distinct lymphoid and myeloid branches arising from the hematopoietic stem cell early during blood cell development. A new study of human hematopoiesis demonstrates that, similar to findings in mice, this split is not as dichotomous as is often presented.

引用

收藏

页码：569 / 570

页数：2

相关论文

共 12 条

[1] IDENTIFICATION IN ADULT BONE-MARROW OF PLURIPOTENT AND RESTRICTED STEM-CELLS OF MYELOID AND LYMPHOID SYSTEMS [J].

ABRAMSON, S ;

MILLER, RG ;

PHILLIPS, RA .

JOURNAL OF EXPERIMENTAL MEDICINE, 1977, 145 (06) :1567-1579

[2] Identification of Flt3+ lympho-myeloid stem cells lacking erythro-megakaryocytic potential:: A revised road map for adult blood lineage commitment [J].

Adolfsson, J ;

Månsson, R ;

Buza-Vidas, N ;

Hultquist, A ;

Liuba, K ;

Jensen, CT ;

Bryder, D ;

Yang, LP ;

Borge, OJ ;

Thoren, LAM ;

Anderson, K ;

Sitnicka, E ;

Sasaki, Y ;

Sigvardsson, M ;

Jacobsen, SEW .

CELL, 2005, 121 (02) :295-306

[3] Relationships between hematopoietic stem cells and lymphocyte progenitors [J].

Baba, Y ;

Pelayo, R ;

Kincade, PW .

TRENDS IN IMMUNOLOGY, 2004, 25 (12) :645-649

[4] Development of human lymphoid cells [J].

Blom, Blanca ;

Spits, Hergen .

ANNUAL REVIEW OF IMMUNOLOGY, 2006, 24 :287-320

[5] INTRODUCTION OF A SELECTABLE GENE INTO PRIMITIVE STEM-CELLS CAPABLE OF LONG-TERM RECONSTITUTION OF THE HEMATOPOIETIC SYSTEM OF W/WV MICE [J].

DICK, JE ;

MAGLI, MC ;

HUSZAR, D ;

PHILLIPS, RA ;

BERNSTEIN, A .

CELL, 1985, 42 (01) :71-79

[6] Revised map of the human progenitor hierarchy shows the origin of macrophages and dendritic cells in early lymphoid development [J].

Doulatov, Sergei ;

Notta, Faiyaz ;

Eppert, Kolja ;

Nguyen, Linh T. ;

Ohashi, Pamela S. ;

Dick, John E. .

NATURE IMMUNOLOGY, 2010, 11 (07) :585-U52

[7] CHRONIC MYELOCYTIC-LEUKEMIA - ORIGIN OF SOME LYMPHOCYTES FROM LEUKEMIC STEM-CELLS [J].

FIALKOW, PJ ;

DENMAN, AM ;

JACOBSON, RJ ;

LOWENTHAL, MN .

JOURNAL OF CLINICAL INVESTIGATION, 1978, 62 (04) :815-823

[8] Redefinition of lymphoid progenitors [J].

Katsura, Y .

NATURE REVIEWS IMMUNOLOGY, 2002, 2 (02) :127-132

[9] EXPRESSION OF A FOREIGN GENE IN MYELOID AND LYMPHOID-CELLS DERIVED FROM MULTIPOTENT HEMATOPOIETIC PRECURSORS [J].

KELLER, G ;

PAIGE, C ;

GILBOA, E ;

WAGNER, EF .

NATURE, 1985, 318 (6042) :149-154

[10] Biology of hematopoietic stem cells and progenitors: Implications for clinical application [J].

Kondo, M ;

Wagers, AJ ;

Manz, MG ;

Prohaska, SS ;

Scherer, DC ;

Beilhack, GE ;

Shizuru, JA ;

Weissman, IL .

ANNUAL REVIEW OF IMMUNOLOGY, 2003, 21 :759-806