Cytotoxicity of colloidal CdSe and CdSe/ZnS nanoparticles

被引：1332

作者：

Kirchner, C

Liedl, T

Kudera, S

Pellegrino, T

Javier, AM

Gaub, HE

Stölzle, S

Fertig, N

Parak, WJ ^{[1
]}

机构：

[1] Univ Munich, Ctr Nanosci, Munich, Germany

[2] Nan Technol GmbH, D-80336 Munich, Germany

来源：

NANO LETTERS | 2005年 / 5卷 / 02期

关键词：

D O I：

10.1021/nl047996m

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Cytotoxicity of CdSe and CdSe/ZnS nanoparticles has been investigated for different surface modifications such as coating with mercaptopropionic acid, silanization, and polymer coating. For all cases, quantitative values for the onset of cytotoxic effects in serum-free culture media are given. These values are correlated with microscope images in which the uptake of the particles by the cells has been investigated. Our data suggest that in addition to the release of toxic Cd2+ ions from the particles also their surface chemistry, in particular their stability toward aggregation, plays an important role for cytotoxic effects. Additional patch clamp experiments investigate effects of the particles on currents through ion channels.

引用

页码：331 / 338

页数：8

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