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Caspofungin

被引：17
作者：
Chandrasekar, PH [1 ]
Manavathu, EK [1 ]
机构：
[1] Wayne State Univ, Dept Med, Div Infect Dis, Detroit, MI 48201 USA
来源：
DRUGS OF TODAY | 2002年 / 38卷 / 12期
关键词：
D O I：
10.1358/dot.2002.38.12.820101
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Available systemically effective antifungal agents for the treatment of invasive fungal infections are few. With the increasing recognition of a need for newer antifungal drugs, caspofungin has been introduced as the first member of a new class of compounds called echinocandins. This paper reviews the chemistry and mechanism of action of caspofungin, its activity in vitro and in animal models, and clinical pharmacokinetics, clinical efficacy and safety in patients. (C) 2002 Prous Science. All rights reserved.
引用
收藏
页码：829 / 846
页数：18
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