Liquid crystals and colloids in water-amiodarone systems

被引：18

作者：

Bouligand, Y

Boury, F

Devoisselle, JM

Fortune, R

Gautier, JC

Girard, D

Maillol, H

Proust, JE

机构：

[1] Univ Angers, Histophys EPHE, F-49100 Angers, France

[2] Univ Montpellier, F-34059 Montpellier, France

[3] Sanofi Rech, F-34082 Montpellier, France

来源：

LANGMUIR | 1998年 / 14卷 / 02期

关键词：

D O I：

10.1021/la962060h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Amiodarone, a molecule used in treatment of heart arrhythmias, presents several metastable states. Transparent sols (50 mg/mL) and gels (100 mg/mL) are obtained by heating amiodarone crystals in water to 70 degrees C and cooling to 20 degrees C. These preparations diluted in water remained transparent above 1.5 mg/mL, but further dilutions resulted in a milky cloud, which was studied by light scattering and photon correlation spectroscopy. A swollen smectic phase appeared at 200 mg/mL and another isotropic gel at 500 mg/mL. This behavior is similar to that of some classical lyotropic liquid crystals.

引用

页码：542 / 546

页数：5

共 24 条

[11]

KELKER H, 1980, HDB LIQUID CRYSTALS, P917

[12]

LIN Z, 1996, LANGMUIR, V12, P1724

[13] CUBIC PHASES OF LIPID-CONTAINING SYSTEMS - STRUCTURE-ANALYSIS AND BIOLOGICAL IMPLICATIONS [J].