Binding Bacteria to Highly Branched Poly(N-isopropyl acrylamide) Modified with Vancomycin Induces the Coil-to-Globule Transition

被引：54

作者：

Shepherd, Joanna ^{[2
,3
]}

Sarker, Prodip ^{[1
]}

Swindells, Kathryn ^{[1
]}

Douglas, Ian ^{[3
]}

MacNeil, Sheila ^{[2
]}

Swanson, Linda ^{[1
]}

Rimmer, Stephen ^{[1
]}

机构：

[1] Univ Sheffield, Dept Chem, Sheffield S3 7HF, S Yorkshire, England

[2] Univ Sheffield, Kroto Res Inst, Dept Mat Engn, Sheffield S3 7HQ, S Yorkshire, England

[3] Univ Sheffield, Sch Clin Dent, Sheffield S10 2TA, S Yorkshire, England

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2010年 / 132卷 / 06期

基金：

英国工程与自然科学研究理事会;

关键词：

STIMULI-RESPONSIVE POLYMERS; TEMPERATURE; INFECTIONS;

D O I：

10.1021/ja907466y

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Binding of highly branched poly(N-isopropylacrylamide) with vancomycin end groups to Staphylococcus aureus induced a coil-to-globule phase transition. The polymers aggregated this Gram-positive bacteria (but not Gram-negative bacteria) over a wide range of temperatures, but cooling to 24-26 degrees C progressed the polymer-bound bacteria through a globule-to-coil phase transition, after which the bacteria were released.

引用

页码：1736 / +

页数：4

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