Correlation between images of silent brain infarction, carotid atherosclerosis and white matter hyperintensity, and plasma levels of acrolein, IL-6 and CRP

被引：53

作者：

Yoshida, Madoka ^{[1
,2
]}

Higashi, Kyohei ^{[1
,2
]}

Kobayashi, Eiichi ^{[3
]}

Saeki, Naokatsu ^{[3
]}

Wakui, Kenji ^{[4
]}

Kusaka, Tadafumi ^{[5
]}

Takizawa, Hirotaka ^{[6
]}

Kashiwado, Koichi ^{[6
]}

Suzuki, Norikazu ^{[7
]}

Fukuda, Kazumasa ^{[8
]}

Nakamura, Takao ^{[8
]}

Watanabe, Sakae ^{[9
]}

Tada, Kei ^{[9
]}

Machi, Yoshiki ^{[1
]}

Mizoi, Mutsumi ^{[2
]}

Toida, Toshihiko ^{[1
]}

Kanzaki, Tetsuto ^{[10
]}

Tomitori, Hideyuki ^{[10
]}

Kashiwagi, Keiko ^{[10
]}

Igarashi, Kazuei ^{[1
,2
]}

机构：

[1] Chiba Univ, Grad Sch Pharmaceut Sci, Chou Ku, Chiba 2608675, Japan

[2] Chiba Univ, Amine Pharma Res Inst, Chiba 2608675, Japan

[3] Chiba Univ, Grad Sch Med, Chiba 2608675, Japan

[4] Chiba Neurosurg Clin, Chiba, Japan

[5] Kusaka Hosp, Chiba, Japan

[6] Portsquare Kashiwado Clin, Chiba, Japan

[7] Suzuki Neurosurg Clin, Chiba, Japan

[8] Chiba Cent Med Ctr, Chiba, Japan

[9] Saisei Hosp, Chiba, Japan

[10] Chiba Inst Sci, Fac Pharm, Chiba, Japan

来源：

ATHEROSCLEROSIS | 2010年 / 211卷 / 02期

关键词：

Protein-conjugated acrolein; IL-6; CRP; Silent brain infarction; Carotid atherosclerosis; White matter hyperintensity; C-REACTIVE PROTEIN; MYOCARDIAL-INFARCTION; CEREBRAL INFARCTION; RISK-FACTOR; STROKE; INTIMA; SENSITIVITY; PROGRESSION; THICKNESS; DIAGNOSIS;

D O I：

10.1016/j.atherosclerosis.2010.03.031

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective: We found previously that the measurement of plasma levels of protein-conjugated acrolein (PC-Acro) together with IL-6 and CRP can be used to identify silent brain infarction (SBI) with high sensitivity and specificity. The aim of this study was to clarify how three biochemical markers are correlated to SBI, carotid atherosclerosis (CA) and white matter hyperintensity (WMH). Methods: The levels of PC-Acro, IL-6 and CRP in plasma were measured by ELISA. SBI and WMH were evaluated by MRI, and CA was evaluated by duplex carotid ultrasonography. Results: A total of 790 apparently healthy volunteers were classified into 260 control, 214 SBI, 263 CA and 245 WMH subjects, which included 187 subjects with two or three pathologies. When the combined measurements of PC-Acro, IL-6 and CRP were evaluated together with age, using a receiver operating characteristic curve and artificial neural networks, the relative risk value (RRV), an indicator of tissue damage, was in the order SBI with CA (0.90) > SBI (0.80) > CA (0.76) > WMH with CA (0.65) > WMH (0.46) > control (0.14). RRV was also correlated with severity in each group of SBI, CA and WMH. Conclusion: The RRV supports the idea that the degree of risk to develop a stroke is in the order SBI > CA > WMH. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

引用

页码：475 / 479

页数：5

共 29 条

[1]

Bokura Hirokazu, 2006, J Stroke Cerebrovasc Dis, V15, P57, DOI 10.1016/j.jstrokecerebrovasdis.2005.11.001

[2]

Brenner H, 1997, STAT MED, V16, P981, DOI 10.1002/(SICI)1097-0258(19970515)16:9<981::AID-SIM510>3.0.CO

[3]

2-N

[4]

Ellenius J, 1997, CLIN CHEM, V43, P1919

[5] P2Y1 Receptor Signaling Enhances Neuroprotection by Astrocytes Against Oxidative Stress via IL-6 Release in Hippocampal Cultures [J].

Fujita, Takumi ;

Tozaki-Saitoh, Hidetoshi ;

Inoue, Kazuhide .

GLIA, 2009, 57 (03) :244-257

[6] Nε-(3-methylpyridinium) lysine, a major antigenic adduct generated in acrolein-modified protein [J].

Furuhata, A ;

Ishii, T ;

Kumazawa, S ;

Yamada, T ;

Nakayama, T ;

Uchida, K .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (49) :48658-48665

[7] Progression of white matter hyperintensities and incidence of new lacunes over a 3-year period - The leukoaraiosis and disability study [J].

Gouw, Alida A. ;

van der Flier, Wiesje M. ;

Fazekas, Franz ;

van Straaten, Elisabeth C. W. ;

Pantoni, Leonardo ;

Poggesi, Anna ;

Inzitari, Domenico ;

Erkinjuntti, Timo ;

Wahlund, Lars O. ;

Waldemar, Gunhild ;

Schmidt, Reinhold ;

Scheltens, Philip ;

Barkhof, Frederik .

STROKE, 2008, 39 (05) :1414-1420

[8] THE MEANING AND USE OF THE AREA UNDER A RECEIVER OPERATING CHARACTERISTIC (ROC) CURVE [J].

HANLEY, JA ;

MCNEIL, BJ .

RADIOLOGY, 1982, 143 (01) :29-36

[9] Relations of serum high-sensitivity C-reactive protein and interleukin-6 levels with silent brain infarction [J].

Hoshi, T ;

Kitagawa, K ;

Yamagami, H ;

Furukado, S ;

Hougaku, H ;

Hori, M .

STROKE, 2005, 36 (04) :768-772

[10] Modulation of cellular function by polyamines [J].

Iarashi, Kazuei ;

Kashiwagi, Keiko .

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2010, 42 (01) :39-51

← 1 2 3 →