Expression of MMPs and TIMPs in liver fibrosis - a systematic review with special emphasis on anti-fibrotic strategies

被引：407

作者：

Hemmann, Stefanie

Graf, Juergen

Roderfeld, Martin

Roeb, Elke

机构：

[1] Univ Hosp Giessen & Marburg GmbH, Dept Med 2, D-35392 Giessen, Germany

[2] Univ Hosp Giessen & Marburg GmbH, Dept Anaesthesiol & Intens Care, D-35033 Marburg, Germany

来源：

JOURNAL OF HEPATOLOGY | 2007年 / 46卷 / 05期

关键词：

liver; fibrosis; MMP; TIMP; matrix; metalloproteinase; tissue; inhibitor; therapy; expression;

D O I：

10.1016/j.jhep.2007.02.003

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

In liver tissue matrix metalloproteinases (MMPs) and their specific inhibitors (tissue inhibitors of metalloproteinases, TIMPs) play a pivotal role in both, fibrogenesis and fibrolysis. The current knowledge of the pathophysiology of liver fibrogenesis with special emphasis on MMPs and TIMPs is presented. A systematic literature search was conducted. All experimental models of liver fibrosis that evaluated a defined anti-fibrotic intervention in vivo or in vitro considering MMPs and TIMPs were selected. The methodological quality of all these publications has been critically appraised using an objective scoring system and the content has been summarized in a table. (C) 2007 European Association for the Study of the Liver. Published by Elsevier BN. All rights reserved.

引用

页码：955 / 975

页数：21

共 186 条

[1] MATRIX METALLOPROTEINASE-2 IS AN INTERSTITIAL COLLAGENASE - INHIBITOR-FREE ENZYME CATALYZES THE CLEAVAGE OF COLLAGEN FIBRILS AND SOLUBLE NATIVE TYPE-I COLLAGEN GENERATING THE SPECIFIC 3/4-LENGTH AND 1/4-LENGTH FRAGMENTS [J].