Expression of MMPs and TIMPs in liver fibrosis - a systematic review with special emphasis on anti-fibrotic strategies

被引：407

作者：

Hemmann, Stefanie

Graf, Juergen

Roderfeld, Martin

Roeb, Elke

机构：

[1] Univ Hosp Giessen & Marburg GmbH, Dept Med 2, D-35392 Giessen, Germany

[2] Univ Hosp Giessen & Marburg GmbH, Dept Anaesthesiol & Intens Care, D-35033 Marburg, Germany

来源：

JOURNAL OF HEPATOLOGY | 2007年 / 46卷 / 05期

关键词：

liver; fibrosis; MMP; TIMP; matrix; metalloproteinase; tissue; inhibitor; therapy; expression;

D O I：

10.1016/j.jhep.2007.02.003

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

In liver tissue matrix metalloproteinases (MMPs) and their specific inhibitors (tissue inhibitors of metalloproteinases, TIMPs) play a pivotal role in both, fibrogenesis and fibrolysis. The current knowledge of the pathophysiology of liver fibrogenesis with special emphasis on MMPs and TIMPs is presented. A systematic literature search was conducted. All experimental models of liver fibrosis that evaluated a defined anti-fibrotic intervention in vivo or in vitro considering MMPs and TIMPs were selected. The methodological quality of all these publications has been critically appraised using an objective scoring system and the content has been summarized in a table. (C) 2007 European Association for the Study of the Liver. Published by Elsevier BN. All rights reserved.

引用

收藏

页码：955 / 975

页数：21

相关论文

共 186 条

[81] TGF-β1 modulates matrix metalloproteinase-13 expression in hepatic stellate cells by complex mechanisms involving p38MAPK, PI3-kinase, AKT, and p70S6k [J].

Lechuga, CG ;

Hernández-Nazara, ZH ;

Rosales, JAD ;

Morris, ER ;

Rincón, AR ;

Rivas-Estilla, AM ;

Esteban-Gamboa, A ;

Rojkind, M .

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2004, 287 (05) :G974-G987

[82] Differential role of p38 in IL-1α induction of MMP-9 and MMP-13 in an established liver myofibroblast cell line [J].

Lee, HS ;

Miau, LH ;

Chen, CH ;

Chiou, LL ;

Huang, GT ;

Yang, PM ;

Sheu, JC .

JOURNAL OF BIOMEDICAL SCIENCE, 2003, 10 (06) :757-765

[83]

Lee SH, 2003, PLANTA MED, V69, P990, DOI 10.1055/s-2003-45143

[84] Tetrandrine prevents tissue inhibitor of metalloproteinase-1 messenger RNA expression in rat liver fibrosis [J].

Lee, SH ;

Nan, JX ;

Sohn, DH .

PHARMACOLOGY & TOXICOLOGY, 2001, 89 (04) :214-216

[85] α-Metanocyte-stimulating hormone gene therapy reverses carbon tetrachloride induced liver fibrosis in mice [J].

Lee, Tsung-Hsing ;

Jawan, Bruno ;

Chou, Wen-Ying ;

Lu, Cheng-Nan ;

Wu, Chia-Ling ;

Kuo, Hsiao-Mei ;

Concejero, Allan M. ;

Wang, Cheng-Haung .

JOURNAL OF GENE MEDICINE, 2006, 8 (06) :764-772

[86]

LI G, 2006, J GENE MED

[87]

Li Xu, 2005, World J Gastroenterol, V11, P4807

[88] Expression and coordinated regulation of matrix metalloproteinases in chronic hepatitis C and hepatitis C virus-induced liver cirrhosis [J].

Lichtinghagen, R ;

Bahr, MJ ;

Wehmeier, M ;

Michels, D ;

Haberkorn, CI ;

Arndt, B ;

Flemming, P ;

Manns, MP ;

Boeker, KHW .

CLINICAL SCIENCE, 2003, 105 (03) :373-382

[89] Matrix metalloproteinase (MMP)-2, MMP-7, and tissue inhibitor of metalloproteinase-1 are closely related to the fibroproliferative process in the liver during chronic hepatitis C [J].

Lichtinghagen, R ;

Michels, D ;

Haberkorn, CI ;

Arndt, B ;

Bahr, M ;

Flemming, P ;

Manns, MP ;

Boeker, KHW .

JOURNAL OF HEPATOLOGY, 2001, 34 (02) :239-247

[90] Treatment of experimental hepatic fibrosis by combinational delivery of urokinase-type plasminogen activator and hepatocyte growth factor genes [J].

Lin, Y ;

Xie, WF ;

Chen, YX ;

Zhang, X ;

Zeng, X ;

Qiang, H ;

Chen, WZ ;

Yang, XJ ;

Han, ZG ;

Zhang, ZB .

LIVER INTERNATIONAL, 2005, 25 (04) :796-807

← 4 5 6 7 8 9 10 11 12 13 →