Leptin in the CNS: much more than a satiety signal

被引：106

作者：

Harvey, J ^{[1
]}

Ashford, MLJ ^{[1
]}

机构：

[1] Univ Dundee, Ninewells Hosp & Med Sch, Dept Pharmacol & Neurosci, Dundee DD1 9SY, Scotland

来源：

NEUROPHARMACOLOGY | 2003年 / 44卷 / 07期

关键词：

leptin; hippocampus; hypothalamus; signalling pathways; ion channels; satiety signal; cognitive function; neuronal excitability;

D O I：

10.1016/S0028-3908(03)00076-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The discovery of the obese gene product, leptin has generated enormous interest in how the periphery signals the status of nutritional stores to specific hypothalamic nuclei involved in regulating feeding and energy balance. However it is emerging that leptin, in addition to its role as a circulating satiety factor, is a multi-faceted hormone that plays a key role in a variety of CNS functions. In this review, we summarise recent progress in leptin biology, with particular focus on its diversity of actions within the CNS, ranging from satiety signal, to regulator of bone formation and inhibitor of neuronal excitability. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：845 / 854

页数：10

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