Leptin in the CNS: much more than a satiety signal

被引：106

作者：

Harvey, J ^{[1
]}

Ashford, MLJ ^{[1
]}

机构：

[1] Univ Dundee, Ninewells Hosp & Med Sch, Dept Pharmacol & Neurosci, Dundee DD1 9SY, Scotland

来源：

NEUROPHARMACOLOGY | 2003年 / 44卷 / 07期

关键词：

leptin; hippocampus; hypothalamus; signalling pathways; ion channels; satiety signal; cognitive function; neuronal excitability;

D O I：

10.1016/S0028-3908(03)00076-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The discovery of the obese gene product, leptin has generated enormous interest in how the periphery signals the status of nutritional stores to specific hypothalamic nuclei involved in regulating feeding and energy balance. However it is emerging that leptin, in addition to its role as a circulating satiety factor, is a multi-faceted hormone that plays a key role in a variety of CNS functions. In this review, we summarise recent progress in leptin biology, with particular focus on its diversity of actions within the CNS, ranging from satiety signal, to regulator of bone formation and inhibitor of neuronal excitability. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：845 / 854

页数：10

共 95 条

[71] BRAIN MYELIN OF GENETICALLY-OBESE MICE [J].

SENA, A ;

SARLIEVE, LL ;

REBEL, G .

JOURNAL OF THE NEUROLOGICAL SCIENCES, 1985, 68 (2-3) :233-244

[72] Leptin inhibits epileptiform-like activity in rat hippocampal neurones via PI 3-kinase-driven activation of BK channels [J].

Shanley, LJ ;

O'Malley, D ;

Irving, AJ ;

Ashford, ML ;

Harvey, J .

JOURNAL OF PHYSIOLOGY-LONDON, 2002, 545 (03) :933-944

[73] Leptin inhibits rat hippocampal neurons via activation of large conductance calcium-activated K+ channels [J].

Shanley, LJ ;

Irving, AJ ;

Rae, MG ;

Ashford, MLJ ;

Harvey, J .

NATURE NEUROSCIENCE, 2002, 5 (04) :299-300

[74]

SHANLEY LJ, 2001, J NEUROSCI, V186, P1

[75] Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling [J].

Shepherd, PR ;

Withers, DJ ;

Siddle, K .

BIOCHEMICAL JOURNAL, 1998, 333 :471-490

[76] Evidence of free and bound leptin in human circulation - Studies in lean and obese subjects and during short-term fasting [J].

Sinha, MK ;

Opentanova, I ;

Ohannesian, JP ;

Kolaczynski, JW ;

Heiman, ML ;

Hale, J ;

Becker, GW ;

Bowsher, RR ;

Stephens, TW ;

Caro, JF .

JOURNAL OF CLINICAL INVESTIGATION, 1996, 98 (06) :1277-1282

[77] Feeding inhibition by neuropeptide Y [J].

Smith, FJ ;

Campfield, LA ;

Moschera, JA ;

Bailon, PS ;

Burn, P .

NATURE, 1996, 382 (6589) :307-307

[78] Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels [J].

Spanswick, D ;

Smith, MA ;

Groppi, VE ;

Logan, SD ;

Ashford, MLJ .

NATURE, 1997, 390 (6659) :521-525

[79] Insulin activates ATP-sensitive K+ channels in hypothalamic neurons of lean, but not obese rats [J].

Spanswick, D ;

Smith, MA ;

Mirshamsi, S ;

Routh, VH ;

Ashford, MLJ .

NATURE NEUROSCIENCE, 2000, 3 (08) :757-758

[80] A role for leptin in brain development [J].

Steppan, CM ;

Swick, AG .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1999, 256 (03) :600-602

← 1 2 3 4 5 6 7 8 9 10 →