Long lasting facilitation of the rabbit cardiac Ca2+ channel:: correlation with the coupling efficiency between charge movement and pore opening

被引：8

作者：

Costantin, JL

Qin, N

Zhou, JM

Platano, D

Birnbaumer, L

Stefani, E

机构：

[1] Univ Calif Los Angeles, Dept Anesthesiol, Los Angeles, CA 90024 USA

[2] Univ Calif Los Angeles, Dept Physiol, Los Angeles, CA 90024 USA

[3] Univ Calif Los Angeles, Dept Biol Chem, Los Angeles, CA 90024 USA

[4] Univ Calif Los Angeles, Sch Med, Los Angeles, CA 90024 USA

[5] Univ Calif Los Angeles, Brain Res Inst, Los Angeles, CA 90024 USA

[6] CONICET, RA-1033 Buenos Aires, DF, Argentina

来源：

FEBS LETTERS | 1998年 / 423卷 / 02期

关键词：

L-type Ca2+ channel; beta subunit; facilitation; charge movement;

D O I：

10.1016/S0014-5793(98)00092-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Facilitation of Ca2+ entry into cells enhances Ca2+ activated events such as transmitter release and stimulation of second messenger systems. We have found a long lasting prepulse facilitation (up to 3-fold) of the cardiac Ca2+ channel alpha(1C)beta(1b) that lasts for tens of seconds without altering current kinetics. The voltage-and time-dependence of the installation of facilitation was characterized as well as the time-and use-dependence of the decay of facilitation. The degree of facilitation was correlated with the coupling efficiency between the charge movement and pore opening channels that were poorly coupled prior to facilitation exhibited the largest facilitation. (C) 1998 Federation of European Biochemical Societies.

引用

页码：213 / 217

页数：5

共 22 条

[1] 3 TYPES OF BOVINE CHROMAFFIN CELL CA-2+ CHANNELS - FACILITATION INCREASES THE OPENING PROBABILITY OF A 27-PS CHANNEL [J].