Synaptic refractory period provides a measure of probability of release in the hippocampus

被引：56

作者：

Hjelmstad, GO

Nicoll, RA

Malenka, RC ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Grad Program Neurosci, San Francisco, CA 94143 USA

[3] Univ Calif San Francisco, Dept Physiol, San Francisco, CA 94143 USA

[4] Univ Calif San Francisco, Dept Mol & Cellular Pharmacol, San Francisco, CA 94143 USA

来源：

NEURON | 1997年 / 19卷 / 06期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

D O I：

10.1016/S0896-6273(00)80421-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Despite extensive research, much controversy remains regarding the locus of expression of long-term potentiation (LTP) in area CA1 of the hippocampus, specifically, whether LTP is accompanied by an increase in the probability of release (p(r)) of synaptic vesicles. We have developed a novel method for assaying p(r) which utilizes the synaptic refractory period-a brief 5-6 ms period following release during which the synapse is incapable of transmission (Stevens and Wang, 1995). We show that this assay is sensitive to a battery of manipulations that affect p(r) but find no change following either NMDA receptor-dependent LTP or long-term depression (LTD).

引用

页码：1309 / 1318

页数：10

共 51 条

[1] AN EVALUATION OF CAUSES FOR UNRELIABILITY OF SYNAPTIC TRANSMISSION [J].