Mitochondria as pharmacological targets

被引：11

作者：

Moncada, S. ^{[1
]}

机构：

[1] UCL, Wolfson Inst Biomed Res, London WC1E 6BT, England

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 2010年 / 160卷 / 02期

关键词：

apoptosis; cancer; metabolic disease; nitric oxide; reactive oxygen species; respiration; signalling; APOPTOSIS; GENERATION; MECHANISMS;

D O I：

10.1111/j.1476-5381.2010.00706.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This article is a commentary on Pravdic et al., pp. 220-232, Puerta et al., pp. 233-245 and Kurz et al. pp. 246-257 of this issue. To view these papers visit http://dx.doi.org/10.1111/j.1476-5381.2010.00698.x http://dx.doi.org/10.1111/j.1476-5381.2010.00663.x and http://dx.doi.org/10.1111/j.1476-5381.2010.00656.x.

引用

页码：217 / 219

页数：3

共 15 条

[1] Mitochondrial free radical generation, oxidative stress, and aging [J].

Cadenas, E ;

Davies, KJA .

FREE RADICAL BIOLOGY AND MEDICINE, 2000, 29 (3-4) :222-230

[2] Overweight, obesity and cancer: Epidemiological evidence and proposed mechanisms [J].

Calle, EE ;

Kaaks, R .

NATURE REVIEWS CANCER, 2004, 4 (08) :579-591

[3] The organization and inheritance of the mitochondrial genome [J].

Chen, XJ ;

Butow, RA .

NATURE REVIEWS GENETICS, 2005, 6 (11) :815-825

[4] Mechanisms by which Bak and Bax permeabilise mitochondria during apoptosis [J].

Dewson, Grant ;

Kluck, Ruth M. .

JOURNAL OF CELL SCIENCE, 2009, 122 (16) :2801-2808

[5] Mitochondria and apoptosis [J].

Green, DR ;

Reed, JC .

SCIENCE, 1998, 281 (5381) :1309-1312

[6] Oxygen sensing by mitochondria at complex III: the paradox of increased reactive oxygen species during hypoxia [J].

Guzy, Robert D. ;

Schumacker, Paul T. .

EXPERIMENTAL PHYSIOLOGY, 2006, 91 (05) :807-819

[7] Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation [J].

Heiden, Matthew G. Vander ;

Cantley, Lewis C. ;

Thompson, Craig B. .

SCIENCE, 2009, 324 (5930) :1029-1033

[8] The metabolic enhancer piracetam ameliorates the impairment of mitochondrial function and neurite outgrowth induced by ß-amyloid peptide [J].

Kurz, C. ;

Ungerer, I. ;

Lipka, U. ;

Kirr, S. ;

Schuett, T. ;

Eckert, A. ;

Leuner, K. ;

Mueller, W. E. .

BRITISH JOURNAL OF PHARMACOLOGY, 2010, 160 (02) :246-257

[9]

Lane N., 2005, Power, Sex, Suicide: Mitochondria and the Meaning of Life

[10] Opinion - Does nitric oxide modulate mitochondrial energy generation and apoptosis? [J].

Moncada, S ;

Erusalimsky, JD .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2002, 3 (03) :214-220

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