The therapeutic promise of the cancer stem cell concept

被引:545
作者
Frank, Natasha Y. [3 ,4 ]
Schatton, Tobias [1 ]
Frank, Markus H. [1 ,2 ]
机构
[1] Childrens Hosp Boston, Transplantat Res Ctr, Boston, MA 02115 USA
[2] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Dermatol, Boston, MA 02115 USA
[3] VA Boston Healthcare Syst, Dept Med, W Roxbury, MA USA
[4] Brigham & Womens Hosp, Div Genet, Boston, MA 02115 USA
关键词
TUMOR-INITIATING CELLS; ACUTE MYELOID-LEUKEMIA; ACUTE LYMPHOBLASTIC-LEUKEMIA; HUMAN-MELANOMA CELLS; ACUTE MYELOBLASTIC-LEUKEMIA; ENDOTHELIAL GROWTH-FACTOR; HUMAN-MALIGNANT MELANOMA; BREAST-CANCER; VASCULOGENIC MIMICRY; PROGENITOR CELLS;
D O I
10.1172/JCI41004
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Cancer stem cells (CSCs) are a subpopulation of tumor cells that selectively possess tumor initiation and self-renewal capacity and the ability to give rise to bulk populations of nontamorigenic cancer cell progeny through differentiation. As we discuss here, they have been prospectively identified in several human malignancies, and their relative abundance in clinical cancer specimens has been correlated with malignant disease progression in human patients. Furthermore, recent findings suggest that clinical cancer progression driven by CSCs may contribute to the failure of existing therapies to consistently eradicate malignant tumors. Therefore, CSC-directed therapeutic approaches might represent translationally relevant strategies to improve clinical cancer therapy, in particular for those malignancies that are currently refractory to conventional anticancer agents directed predominantly at tumor bulk populations.
引用
收藏
页码:41 / 50
页数:10
相关论文
共 125 条
[1]  
Abraham BK, 2005, CLIN CANCER RES, V11, P1154
[2]   Prospective identification of tumorigenic breast cancer cells [J].
Al-Hajj, M ;
Wicha, MS ;
Benito-Hernandez, A ;
Morrison, SJ ;
Clarke, MF .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (07) :3983-3988
[3]   A Proof-Of-Principle Study of Epigenetic Therapy Added to Neoadjuvant Doxorubicin Cyclophosphamide for Locally Advanced Breast Cancer [J].
Arce, Claudia ;
Perez-Plasencia, Carlos ;
Gonzalez-Fierro, Aurora ;
de la Cruz-Hernandez, Erick ;
Revilla-Vazquez, Alma ;
Chavez-Blanco, Alma ;
Trejo-Becerril, Catalina ;
Perez-Cardenas, Enrique ;
Taja-Chayeb, Lucia ;
Bargallo, Enrique ;
Villarreal, Patricia ;
Ramirez, Teresa ;
Vela, Teresa ;
Candelaria, Myrna ;
Camargo, Maria F. ;
Robles, Elizabeth ;
Duenas-Gonzalez, Alfonso .
PLOS ONE, 2006, 1 (01)
[4]   Targeting cancer stem cells through L1CAM suppresses glioma growth [J].
Bao, Shideng ;
Wu, Qiulian ;
Li, Zhizhong ;
Sathornsumetee, Sith ;
Wang, Hui ;
McLendon, Roger E. ;
Hjehneland, Anita B. ;
Rich, Jeremy N. .
CANCER RESEARCH, 2008, 68 (15) :6043-6048
[5]   Glioma stem cells promote radioresistance by preferential activation of the DNA damage response [J].
Bao, Shideng ;
Wu, Qiulian ;
McLendon, Roger E. ;
Hao, Yueling ;
Shi, Qing ;
Hjelmeland, Anita B. ;
Dewhirst, Mark W. ;
Bigner, Darell D. ;
Rich, Jeremy N. .
NATURE, 2006, 444 (7120) :756-760
[6]   Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor [J].
Bao, Shideng ;
Wu, Qiulian ;
Sathornsumetee, Sith ;
Hao, Yueling ;
Li, Zhizhong ;
Hjelmeland, Anita B. ;
Shi, Oing ;
McLendon, Roger E. ;
Bigner, Darell D. ;
Rich, Jeremy N. .
CANCER RESEARCH, 2006, 66 (16) :7843-7848
[7]   Crypt stem cells as the cells-of-origin of intestinal cancer [J].
Barker, Nick ;
Ridgway, Rachel A. ;
van Es, Johan H. ;
van de Wetering, Marc ;
Begthel, Harry ;
van den Born, Maaike ;
Danenberg, Esther ;
Clarke, Alan R. ;
Sansom, Owen J. ;
Clevers, Hans .
NATURE, 2009, 457 (7229) :608-U119
[8]   CD133+ and CD133- glioblastoma-derived cancer stem cells show differential growth characteristics and molecular profiles [J].
Beier, Dagmar ;
Hau, Peter ;
Proescholdt, Martin ;
Lohmeier, Annette ;
Wischhusen, Joerg ;
Oefner, Peter J. ;
Aigner, Ludwig ;
Brawanski, Alexander ;
Bogdahn, Ulrich ;
Beier, Christoph P. .
CANCER RESEARCH, 2007, 67 (09) :4010-4015
[9]   Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell [J].
Bonnet, D ;
Dick, JE .
NATURE MEDICINE, 1997, 3 (07) :730-737
[10]   A QUANTITATIVE ASSAY FOR NUMBER OF MURINE LYMPHOMA CELLS CAPABLE OF PROLIFERATION IN VIVO [J].
BRUCE, WR ;
VANDERGA.H .
NATURE, 1963, 199 (488) :79-&