The therapeutic promise of the cancer stem cell concept

被引：545

作者：

Frank, Natasha Y. ^{[3
,4
]}

Schatton, Tobias ^{[1
]}

Frank, Markus H. ^{[1
,2
]}

机构：

[1] Childrens Hosp Boston, Transplantat Res Ctr, Boston, MA 02115 USA

[2] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Dermatol, Boston, MA 02115 USA

[3] VA Boston Healthcare Syst, Dept Med, W Roxbury, MA USA

[4] Brigham & Womens Hosp, Div Genet, Boston, MA 02115 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2010年 / 120卷 / 01期

关键词：

TUMOR-INITIATING CELLS; ACUTE MYELOID-LEUKEMIA; ACUTE LYMPHOBLASTIC-LEUKEMIA; HUMAN-MELANOMA CELLS; ACUTE MYELOBLASTIC-LEUKEMIA; ENDOTHELIAL GROWTH-FACTOR; HUMAN-MALIGNANT MELANOMA; BREAST-CANCER; VASCULOGENIC MIMICRY; PROGENITOR CELLS;

D O I：

10.1172/JCI41004

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Cancer stem cells (CSCs) are a subpopulation of tumor cells that selectively possess tumor initiation and self-renewal capacity and the ability to give rise to bulk populations of nontamorigenic cancer cell progeny through differentiation. As we discuss here, they have been prospectively identified in several human malignancies, and their relative abundance in clinical cancer specimens has been correlated with malignant disease progression in human patients. Furthermore, recent findings suggest that clinical cancer progression driven by CSCs may contribute to the failure of existing therapies to consistently eradicate malignant tumors. Therefore, CSC-directed therapeutic approaches might represent translationally relevant strategies to improve clinical cancer therapy, in particular for those malignancies that are currently refractory to conventional anticancer agents directed predominantly at tumor bulk populations.

引用

页码：41 / 50

页数：10

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