An Effective Microwave-Induced Iodine-Catalyzed Method for the Synthesis of Quinoxalines via Condensation of 1,2-Diamines with 1,2-Dicarbonyl Compounds

被引：60

作者：

Bandyopadhyay, Debasish ^{[1
]}

Mukherjee, Sanghamitra ^{[1
]}

Rodriguez, Robert R. ^{[1
]}

Banik, Bimal K. ^{[1
]}

机构：

[1] Univ Texas Pan Amer, Dept Chem, Edinburg, TX 78541 USA

来源：

MOLECULES | 2010年 / 15卷 / 06期

关键词：

iodine; microwave; quinoxalines; amines; dicarbonyl compounds; POLYCYCLIC AROMATIC-COMPOUNDS; ANTICANCER AGENTS; BIOLOGICAL EVALUATION; BETA-LACTAMS; DERIVATIVES; CHRYSENE; ACID;

D O I：

10.3390/molecules15064207

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

A microwave-induced iodine-catalyzed simple, rapid and convenient synthesis of different types of quinoxalines via condensation of 1,2-diamines with 1,2-dicarbonyl compounds has been accomplished with an excellent yield.

引用

页码：4207 / 4212

页数：6

共 15 条

[1]

BADRAN MM, 2001, B PHARM SCI, V24, P135

[2]

Bailly C, 1999, ANTI-CANCER DRUG DES, V14, P291

[3]

Synthesis of anticancer β-lactams:: mechanism of action [J].

Banik, BK ;

Becker, FF ;

Banik, I .

BIOORGANIC & MEDICINAL CHEMISTRY, 2004, 12 (10) :2523-2528

[4]

Synthesis, electrophilic substitution and structure-activity relationship studies of polycyclic aromatic compounds towards the development of anticancer agents [J].

Banik, BK ;

Becker, FF .

CURRENT MEDICINAL CHEMISTRY, 2001, 8 (12) :1513-1533

[5]

Polycyclic aromatic compounds as anticancer agents: Structure-activity relationships of chrysene and pyrene derivatives [J].

Banik, BK ;

Becker, FF .

BIOORGANIC & MEDICINAL CHEMISTRY, 2001, 9 (03) :593-605

[6]

Stereoselective synthesis of β-lactams with polyaromatic imines:: Entry to new and novel anticancer agents [J].

Banik, I ;

Becker, FF ;

Banik, BK .

JOURNAL OF MEDICINAL CHEMISTRY, 2003, 46 (01) :12-15

[7]

Polycyclic aromatic compounds as anticancer agents: Synthesis and biological evaluation of some chrysene derivatives [J].

Becker, FF ;

Banik, BK .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1998, 8 (20) :2877-2880

[8]

Polycyclic aromatic compounds as anticancer agents: Synthesis and biological evaluation of dibenzofluorene derivatives [J].

Becker, FF ;

Mukhopadhyay, C ;

Hackfeld, L ;

Banik, I ;

Banik, BK .

BIOORGANIC & MEDICINAL CHEMISTRY, 2000, 8 (12) :2693-2699

[9]

Design, synthesis, and biological evaluation of analogues of the antitumor agent, 2-{4-[(7-chloro-2-quinoxalinyl)oxy]phenoxy}propionic acid (XK469) [J].

Hazeldine, ST ;

Polin, L ;

Kushner, J ;

Paluch, J ;

White, K ;

Edelstein, M ;

Palomino, E ;

Corbett, TH ;

Horwitz, JP .

JOURNAL OF MEDICINAL CHEMISTRY, 2001, 44 (11) :1758-1776

[10]

Recent advances in the solid-phase combinatorial synthetic strategies for the quinoxaline, quinazoline and benzimidazole based privileged structures [J].

Kamal, A ;

Reddy, KL ;

Devaiah, V ;

Shankaraiah, N ;

Rao, MV .

MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2006, 6 (01) :71-89

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