Decision checkpoints in the thymus

被引：219

作者：

Carpenter, Andrea C. ^{[1
]}

Bosselut, Remy ^{[1
]}

机构：

[1] NCI, Lab Immune Cell Biol, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

来源：

NATURE IMMUNOLOGY | 2010年 / 11卷 / 08期

基金：

美国国家卫生研究院;

关键词：

T-CELL-RECEPTOR; THYMOCYTE POSITIVE SELECTION; DELTA LINEAGE FATE; GAMMA-DELTA; ALPHA-BETA; ZINC-FINGER; TRANSCRIPTION FACTORS; CD8; LINEAGE; PHOSPHATIDYLINOSITOL; 3-KINASE; INTERLEUKIN-7; RECEPTOR;

D O I：

10.1038/ni.1887

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The development of T cells in the thymus involves several differentiation and proliferation events, during which hematopoietic precursors give rise to T cells ready to respond to antigen stimulation and undergo effector differentiation. This review addresses signaling and transcriptional checkpoints that control the intrathymic journey of T cell precursors. We focus on the divergence of alpha beta and gamma delta lineage cells and the elaboration of the alpha beta T cell repertoire, with special emphasis on the emergence of transcriptional programs that direct lineage decisions.

引用

页码：666 / 673

页数：8

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