Decision checkpoints in the thymus

被引：219

作者：

Carpenter, Andrea C. ^{[1
]}

Bosselut, Remy ^{[1
]}

机构：

[1] NCI, Lab Immune Cell Biol, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

来源：

NATURE IMMUNOLOGY | 2010年 / 11卷 / 08期

基金：

美国国家卫生研究院;

关键词：

T-CELL-RECEPTOR; THYMOCYTE POSITIVE SELECTION; DELTA LINEAGE FATE; GAMMA-DELTA; ALPHA-BETA; ZINC-FINGER; TRANSCRIPTION FACTORS; CD8; LINEAGE; PHOSPHATIDYLINOSITOL; 3-KINASE; INTERLEUKIN-7; RECEPTOR;

D O I：

10.1038/ni.1887

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The development of T cells in the thymus involves several differentiation and proliferation events, during which hematopoietic precursors give rise to T cells ready to respond to antigen stimulation and undergo effector differentiation. This review addresses signaling and transcriptional checkpoints that control the intrathymic journey of T cell precursors. We focus on the divergence of alpha beta and gamma delta lineage cells and the elaboration of the alpha beta T cell repertoire, with special emphasis on the emergence of transcriptional programs that direct lineage decisions.

引用

页码：666 / 673

页数：8

共 130 条

[71] Regulation of lymphoid development, differentiation, and function by the notch pathway [J].

Maillard, I ;

Fang, T ;

Pear, WS .

ANNUAL REVIEW OF IMMUNOLOGY, 2005, 23 :945-974

[72] The requirement for Notch signaling at the β-selection checkpoint in vivo is absolute and independent of the pre-T cell receptor [J].

Maillard, Ivan ;

Tu, LiLi ;

Sambandam, Arivazhagan ;

Yashiro-Ohtani, Yumi ;

Millholland, John ;

Keeshan, Karen ;

Shestova, Olga ;

Xu, Lanwei ;

Bhandoola, Avinash ;

Pear, Warren S. .

JOURNAL OF EXPERIMENTAL MEDICINE, 2006, 203 (10) :2239-2245

[73] Evolutionarily conserved amino acids that control TCR-MHC interaction [J].

Marrack, Philippa ;

Scott-Browne, James P. ;

Dai, Shaodong ;

Gapin, Laurent ;

Kappler, John W. .

ANNUAL REVIEW OF IMMUNOLOGY, 2008, 26 :171-203

[74] MHC class II-specific T cells can develop in the CD8 lineage when CD4 is absent [J].

Matechak, EO ;

Killeen, N ;

Hedrick, SM ;

Fowlkes, BJ .

IMMUNITY, 1996, 4 (04) :337-347

[75] Aire [J].

Mathis, Diane ;

Benoist, Christophe .

ANNUAL REVIEW OF IMMUNOLOGY, 2009, 27 :287-312

[76] RAG: a recombinase diversified [J].

Matthews, Adam G. W. ;

Oettinger, Marjorie A. .

NATURE IMMUNOLOGY, 2009, 10 (08) :817-821

[77] Thymic emigration revisited [J].

McCaughtry, Tom M. ;

Wilken, Matthew S. ;

Hogquist, Kristin A. .

JOURNAL OF EXPERIMENTAL MEDICINE, 2007, 204 (11) :2513-2520

[78] Regulation of γδ versus αβ T lymphocyte differentiation by the transcription factor SOX13 [J].

Melichar, Heather J. ;

Narayan, Kavitha ;

Der, Sandy D. ;

Hiraoka, Yoshiki ;

Gardiol, Noemie ;

Jeannet, Gregoire ;

Held, Werner ;

Chambers, Cynthia A. ;

Kang, Joonsoo .

SCIENCE, 2007, 315 (5809) :230-233

[79] Cascading suppression of transcriptional silencers by ThPOK seals helper T cell fate [J].

Muroi, Sawako ;

Naoe, Yoshinori ;

Miyamoto, Chizuko ;

Akiyama, Kaori ;

Ikawa, Tomokatsu ;

Masuda, Kyoko ;

Kawamoto, Hiroshi ;

Taniuchi, Ichiro .

NATURE IMMUNOLOGY, 2008, 9 (10) :1113-1121

[80] Cathepsin L: Critical role in Ii degradation and CD4 T cell selection in the thymus [J].

Nakagawa, T ;

Roth, W ;

Wong, P ;

Nelson, A ;

Farr, A ;

Deussing, J ;

Villadangos, JA ;

Ploegh, H ;

Peters, C ;

Rudensky, AY .

SCIENCE, 1998, 280 (5362) :450-453

← 3 4 5 6 7 8 9 10 11 12 →