Quantitative structure-activity relationships of mutagenic and carcinogenic aromatic amines

被引：163

作者：

Benigni, R

Giuliani, A

Franke, R

Gruska, A

机构：

[1] Ist Super Sanita, Comparat Toxicol & Ecotoxicol Lab, I-00161 Rome, Italy

[2] Consulting Drug Design GbR, D-16352 Basdorf, Germany

来源：

CHEMICAL REVIEWS | 2000年 / 100卷 / 10期

关键词：

D O I：

10.1021/cr9901079

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The toxicological problems posed by the aromatic amines, together with evidence on their mechanisms of action were examined. Quantitative structure-activity relationships (QSAR) were reviewed for the experimental results on the mutagenic and carcinogenic properties of the amines. The bioactivation mechanism for aromatic amines was found to be the same in carcinogenesis and mutagenesis. In the carcinogenic potency analysis, ring substuents were proposed to exert electronic and steric effects. The results reveal that QSARs for the aromatic amines show hydrophobicity in the activity of mutagens and carcinogens.

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页码：3697 / 3714

页数：18

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