Effects of anti-IL-5 monoclonal antibody on the murine model of nasal allergy

被引：20

作者：

Asakura, K ^{[1
]}

Saito, H ^{[1
]}

Watanabe, M ^{[1
]}

Ogasawara, H ^{[1
]}

Matsui, T ^{[1
]}

Kataura, A ^{[1
]}

机构：

[1] Sapporo Med Univ, Dept Otolaryngol, Chuo Ku, Sapporo, Hokkaido 060, Japan

来源：

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | 1998年 / 116卷 / 01期

关键词：

nasal allergy; anti-IL-5 monoclonal antibody; murine model;

D O I：

10.1159/000023924

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

IL-5 is known to be closely related to the infiltration, activation and proliferation of eosinophils. In this study, we evaluated the in vivo effects of anti-IL-5 monoclonal antibody (mAb) in the murine model of nasal allergy. The mAb treatment inhibited the antigen-induced late phase eosinophilia, but had no effects on the number of basophilic cells. It also inhibited early phase nasal symptoms, and tended to inhibit histamine hypersensitivity. These findings suggest that IL-5 plays an important role in the pathogenesis of allergic nasal disorders.

引用

页码：49 / 52

页数：4

共 15 条

[1]

BRADDING P, 1993, J IMMUNOL, V151, P3853

[2] ANTI-IL-5 MONOCLONAL-ANTIBODY INHIBITS ALLERGIC LATE PHASE BRONCHIAL EOSINOPHILIA IN GUINEA-PIGS - A THERAPEUTIC APPROACH [J].

CHAND, N ;

HARRISON, JE ;

ROONEY, S ;

PILLAR, J ;

JAKUBICKI, R ;

NOLAN, K ;

DIAMANTIS, W ;

SOFIA, RD .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1992, 211 (01) :121-123

[3]

DURHAM SR, 1992, J IMMUNOL, V148, P2390

[4]

FUJISAWA T, 1990, J IMMUNOL, V144, P642

[5] INTERLEUKIN-5 MODULATES EOSINOPHIL ACCUMULATION IN ALLERGIC GUINEA-PIG LUNG [J].

GULBENKIAN, AR ;

EGAN, RW ;

FERNANDEZ, X ;

JONES, H ;

KREUTNER, W ;

KUNG, T ;

PAYVANDI, F ;

SULLIVAN, L ;

ZURCHER, JA ;

WATNICK, AS .

AMERICAN REVIEW OF RESPIRATORY DISEASE, 1992, 146 (01) :263-266

[6] PRODUCTION OF A MONOCLONAL-ANTIBODY USEFUL IN THE MOLECULAR CHARACTERIZATION OF MURINE T-CELL-REPLACING FACTOR B-CELL GROWTH FACTOR-II [J].

HARADA, N ;

TAKAHASHI, T ;

MATSUMOTO, M ;

KINASHI, T ;

OHARA, J ;

KIKUCHI, Y ;

KOYAMA, N ;

SEVERINSON, E ;

YAOITA, Y ;

HONJO, T ;

YAMAGUCHI, N ;

TOMINAGA, A ;

TAKATSU, K .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (13) :4581-4585

[7] ENHANCEMENT OF HUMAN BASOPHIL HISTAMINE-RELEASE BY INTERLEUKIN-5 [J].

HIRAI, K ;

YAMAGUCHI, M ;

MISAKI, Y ;

TAKAISHI, T ;

OHTA, K ;

MORITA, Y ;

ITO, K ;

MIYAMOTO, T .

JOURNAL OF EXPERIMENTAL MEDICINE, 1990, 172 (05) :1525-1528

[8] INHIBITORY EFFECT OF THE TRFK-5 ANTI-IL-5 ANTIBODY IN A GUINEA-PIG MODEL OF ASTHMA [J].

MAUSER, PJ ;

PITMAN, A ;

WITT, A ;

FERNANDEZ, X ;

ZURCHER, J ;

KUNG, T ;

JONES, H ;

WATNICK, AS ;

EGAN, RW ;

KREUTNER, W ;

ADAMS, GK .

AMERICAN REVIEW OF RESPIRATORY DISEASE, 1993, 148 (06) :1623-1627

[9]

ROTHENBERG ME, 1989, J IMMUNOL, V143, P2311

[10] Topical antigen provocation increases the number of immunoreactive IL-4-, IL-5 and IL-6-positive cells in the nasal mucosa of patients with perennial allergic rhinitis [J].

Saito, H ;

Asakura, K ;

Ogasawara, H ;

Watanabe, M ;

Kataura, A .

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 1997, 114 (01) :81-85

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