Brain region-specific changes in the expression of calcium sensor proteins after repeated applications of ketamine to rats

被引:31
作者
Bernstein, HG
Becker, A
Keilhoff, G
Spilker, C
Gorczyca, WA
Braunewell, KH
Grecksch, G
机构
[1] Univ Magdeburg, Dept Psychiat, D-39120 Magdeburg, Germany
[2] Univ Magdeburg, Inst Pharmacol & Toxicol, D-39120 Magdeburg, Germany
[3] Univ Magdeburg, Inst Med Neurobiol, D-39120 Magdeburg, Germany
[4] Humboldt Univ, Ctr Res Neurosci, Signal Transduct Res Grp, Berlin, Germany
[5] Ludwik Hirszfeld Inst Immunol & Expt Therapy, Wroclaw, Poland
关键词
ketamine; repeated application; immunohistochemistry; visinin-like protein-1; visinin-like protein-3; hippocalcin; schizophrenia-relevant changes;
D O I
10.1016/S0304-3940(02)01482-9
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
We investigated the cellular distribution of three calcium sensor proteins, visinin-like protein-1 (VILIP-1), VILIP-3, and hippocalcin, in different rat brain areas after repeated administration of the non-competitive N-methyl-D-aspartate receptor antagonist ketamine. In comparison to controls we observed an increase in the density of VILIP-I immunoreactive (IR) hippocampal interneurons and presubicular nerve cells in ketamine treated rats, whereas the density of VILIP-I expressing cells was decreased in the Nuc. accumbens of these rats. No alterations were seen in the distribution patterns of VILIP-3. The density of hippocalcin-expressing neurons was increased in the cingulate cortex of drug-treated rats. Our experiments show that repeated injections of subanesthetic doses of ketamine induce subtle changes in the cellular distribution of calcium sensor proteins which in part resemble those recently described in postmortem brains of human schizophrenics [Bernstein, H.-G., Braunewell, K.-H., Spilker, C., Danos, P., Baumann, B., Funke, S., Diekmann, S., Gundelfinger, E.D. and Bogerts, B., NeuroReport, 13 (2002) 393-396]. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:95 / 98
页数:4
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