The frequency of resistant mutant virus before antiviral therapy

被引:106
作者
Ribeiro, RM
Bonhoeffer, S
Nowak, MA
机构
[1] Univ Oxford, Dept Zool, Oxford OX1 3PS, England
[2] Aaron Diamond AIDS Res Ctr, New York, NY USA
基金
英国惠康基金;
关键词
antiviral therapy; mathematical model; resistant mutant; viral load;
D O I
10.1097/00002030-199805000-00006
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Objective: To calculate the expected prevalence of resistant HIV mutants before antiviral therapy. Design: HIV replication generates virus mutants. The prevalence of these mutants is determined by mutation and selection/fitness. Some mutations will confer drug resistance and it is crucial for the success of antiviral drug therapy to determine whether these resistant viruses are present before the initiation of therapy. Methods: A quasispecies equation was used to calculate the expected frequency of drug-resistant virus prior to therapy. Results and conclusions: We show how the pretreatment frequency of resistant virus depends on the number of point mutations between wild-type and mutant virus, the selective disadvantage of the resistant mutant and the intermediate mutants, and the mutation rate. (C) 1998 Rapid Science Ltd.
引用
收藏
页码:461 / 465
页数:5
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