Responsiveness of generic health-related quality of life measures in stroke

被引：121

作者：

Simon Pickard, A

Johnson, JA

Feeny, DH

机构：

[1] Univ Illinois, Coll Pharm, Ctr Pharmacoecon Res, Chicago, IL 60612 USA

[2] Univ Illinois, Coll Pharm, Dept Pharm Practice, Chicago, IL 60612 USA

[3] Univ Alberta, Fac Med & Dent, Dept Publ Hlth Sci, Edmonton, AB T6G 2M7, Canada

[4] Univ Alberta, Inst Hlth Econ, Edmonton, AB T6G 2M7, Canada

[5] Univ Alberta, Fac Pharm & Pharmaceut Sci, Edmonton, AB T6G 2M7, Canada

[6] Hlth Util Inc, Dundas, ON, Canada

来源：

QUALITY OF LIFE RESEARCH | 2005年 / 14卷 / 01期

基金：

加拿大健康研究院;

关键词：

cerebrovascular disease; health-related quality of life; health status indicators; longitudinal studies;

D O I：

10.1007/s11136-004-3928-3

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

Objective: To compare. five preference-based generic measures of health-related quality of life (HRQOL) in terms of change scores, correlations among change scores, responsiveness, and quality adjusted life-years (QALYs) gained. Design: Observational longitudinal cohort study where clinical measures and self-assessed HRQOL measures were administered to stroke patients at baseline and at 6 months. Patients were categorized as 'stable', 'some improvement' and 'large improvement' using the Barthel Index, Modified Rankin Scale (MRS), and Center for Epidemiologic Studies Depression Scale (CES-D). For each group, paired t-tests and variants of effect size were used to compare the responsiveness of preference-based HRQOL summary scores, including the EQ-5D VAS and index-based score, SF-6D, and Health Utilities Index (HUI) Mark 2 (HUI2) and Mark 3 (HUI3) overall utility scores. Results: Ninety-eight of 124 (79%) patients completed the 6-month follow-up. Change scores of the EQ-Index, HUI2, and HUI3 were strongly correlated with changes in the Barthel Index and MRS, while the EQ-5D VAS had higher correlation with CES-D change scores than the other measures. The SF-6D, HUI3, and EQ-Index were generally more responsive than the HUI2 and EQ-5D Visual analogue scale (EQ-VAS). QALY estimates based on the EQ-5D index and HUI3 were twice as large as estimates based on the SF-6D and HUI2. Conclusions: The results of this study may assist in informing the selection of a preference-based generic HRQOL measure, although choice will also depend on study goals and context. We would caution against the generalization of the study results on responsiveness to conditions when more subtle change is expected..

引用

页码：207 / 219

页数：13

共 61 条

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