A neuro-stimulus chip with telemetry unit for retinal prosthetic device

被引:280
作者
Liu, WT [1 ]
Vichienchom, K
Clements, M
DeMarco, SC
Hughes, C
McGucken, E
Humayun, MS
de Juan, E
Weiland, JD
Greenberg, R
机构
[1] N Carolina State Univ, Dept Elect & Comp Engn, Raleigh, NC 27695 USA
[2] Johns Hopkins Univ, Wilmer Ophthalmol Inst, Baltimore, MD 21287 USA
基金
美国国家科学基金会;
关键词
biomedical telemetry; neuro-stimulator; retinal prosthesis;
D O I
10.1109/4.871327
中图分类号
TM [电工技术]; TN [电子技术、通信技术];
学科分类号
0808 ; 0809 ;
摘要
In this retinal prosthesis project, a rehabilitative device is designed to replace the functionality of defective photoreceptors in patients suffering from retinitis pigmentosa (RP) and age-related macular degeneration (AMD), The device consists of an extraocular and an intraocular unit. The implantable component receives power and a data signal via a telemetric inductive link between the two units. The extraocular unit includes a video camera and video processing board, a telemetry protocol encoder chip, and an RF amplifier and primary coil. The intraocular unit consists of a secondary coil, a rectifier and regulator, a retinal chip with a telemetry protocol decoder, a stimulus signal generator, and an electrode array, This paper focuses on the design, fabrication, and testing of a microchip which serves as the telemetry protocol decoder and stimulus signal generator. It is fabricated by MOSIS with 1.2-mm CMOS technology and was demonstrated to provide the desired biphasic current stimulus pulses for an array of 100 retinal electrodes at video frame fates.
引用
收藏
页码:1487 / 1497
页数:11
相关论文
共 22 条
  • [1] BOUVIER J, 1997, IEEE INT SOL STAT CI, P296
  • [2] CHOW A, 1997, NEUROSCI LETT, P13
  • [3] ANALYSIS OF RESONANT COUPLED COILS IN THE DESIGN OF RADIO-FREQUENCY TRANS-CUTANEOUS LINKS
    DONALDSON, ND
    PERKINS, TA
    [J]. MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING, 1983, 21 (05) : 612 - 627
  • [4] Learning retina implants with epiretinal contacts
    Eckmiller, R
    [J]. OPHTHALMIC RESEARCH, 1997, 29 (05) : 281 - 289
  • [5] MUTUAL INDUCTANCE OF AIR-CORED COILS - EFFECT ON DESIGN OF RADIO-FREQUENCY COUPLED IMPLANTS
    FLACK, FC
    JAMES, ED
    SCHLAPP, DM
    [J]. MEDICAL & BIOLOGICAL ENGINEERING, 1971, 9 (02): : 79 - &
  • [6] Gray P. R., 1993, ANAL DESIGN ANALOG I
  • [7] GREENBERG R, 1998, THESIS J HOPKINS U B
  • [8] Pattern electrical stimulation of the human retina
    Humayun, MS
    de Juan, E
    Weiland, JD
    Dagnelie, G
    Katona, S
    Greenberg, R
    Suzuki, S
    [J]. VISION RESEARCH, 1999, 39 (15) : 2569 - 2576
  • [9] Visual perception elicited by electrical stimulation of retina in blind humans
    Humayun, MS
    deJuan, E
    Dagnelie, G
    Greenberg, RJ
    Prost, RH
    Phillips, DH
    [J]. ARCHIVES OF OPHTHALMOLOGY, 1996, 114 (01) : 40 - 46
  • [10] Johns D.A., 2008, Analog integrated circuit design