Neutral effect of recombination on base composition in Drosophila

被引：70

作者：

Marais, G ^{[1
]}

Mouchiroud, D ^{[1
]}

Duret, L ^{[1
]}

机构：

[1] Univ Lyon 1, Lab Biometrie & Biol Evolut, UMR 5558, F-69622 Villeurbanne, France

来源：

GENETICS RESEARCH | 2003年 / 81卷 / 02期

关键词：

D O I：

10.1017/S0016672302006079

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Recombination is thought to have various evolutionary effects on genome evolution. In this study, we investigated the relationship between the base composition and recombination rate in the Drosophila melanogaster genome. Because of a current debate about the accuracy of the estimates of recombination rate in Drosophila, we used eight different measures of recombination rate from recent work. We confirmed that the G + C content of large introns and flanking regions is positively correlated with recombination rate, suggesting that recombination has a neutral effect on base composition in Drosophila. We also confirmed that this neutral effect of recombination is the main determinant of the correlation between synonymous codon usage bias and recombination rate in Drosophila.

引用

页码：79 / 87

页数：9

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