FR252921, a novel immunosuppressive agent isolated from Pseudomonas fluorescens No. 408813 -: I.: Taxonomy, fermentation, isolation, physico-chemical properties and biological activities of FR252921, FR252922 and FR256523

被引：17

作者：

Fujine, K ^{[1
]}

Tanaka, M ^{[1
]}

Ohsumi, K ^{[1
]}

Hashimoto, M ^{[1
]}

Takase, S ^{[1
]}

Ueda, H ^{[1
]}

Hino, M ^{[1
]}

Fujii, T ^{[1
]}

机构：

[1] Fujisawa Pharmaceut Co Ltd, Exploratory Res Labs, Tsukuba, Ibaraki 3002698, Japan

来源：

JOURNAL OF ANTIBIOTICS | 2003年 / 56卷 / 02期

关键词：

D O I：

10.7164/antibiotics.56.55

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Novel immunosuppressive agents, FR252921, FR252922 and FR256523 were isolated from the cultured broth of a bacterial strain No. 408813. The strain was identified Pseudomonas fluorescens from morphological and physiological characteristics. FR252921, FR252922 and FR256523, novel compounds containing macrolactone ring,showed immunosuppressive activity against murine splenocyte proliferation stimulated with lipopolysaccharide (LPS) or anti-CD3 mAb in vitro.

引用

页码：55 / 61

页数：7

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