FR252921, a novel immunosuppressive agent isolated from Pseudomona fluorescens No. 408813 -: III.: In vivo activities

被引：15

作者：

Fujine, K ^{[1
]}

Ueda, H ^{[1
]}

Hino, M ^{[1
]}

Fujii, T ^{[1
]}

机构：

[1] Fujisawa Pharmaceut Co Ltd, Exploratory Res Labs, Tsukuba, Ibaraki 3002698, Japan

来源：

JOURNAL OF ANTIBIOTICS | 2003年 / 56卷 / 02期

关键词：

D O I：

10.7164/antibiotics.56.68

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A novel immunosuppressive agent, FR252921 was isolated from the cultured broth of a species of Pseudomonas fluorescens. We have shown that FR252921 inhibit activating protein-1 (AP-1) transcription activity and act dominantly against antigen presenting cells comparing to T cell. Possibility of FR252921 as concomitant drug of FK506, T-cell specific inhibitor was evaluated. FR252921 showed synergy with FK506 in immunosuppressive activity both in splenic proliferation and in murine skin transplantation.

引用

页码：68 / 71

页数：4

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