Design of chiral picen-based metal complexes for molecular recognition of α-aminoacids and nucleic acids

被引：66

作者：

Aldrich-Wright, JR

Vagg, RS

Williams, PA ^{[1
]}

机构：

[1] Univ Western Sydney Nepean, Fac Sci & Technol, Nepean, ON 2747, Canada

[2] Univ Western Sydney Macarthur, Dept Chem, Macarthur, NSW 2560, Australia

[3] Macquarie Univ, Sch Chem, N Ryde, NSW 2109, Australia

来源：

COORDINATION CHEMISTRY REVIEWS | 1997年 / 166卷

关键词：

molecular recognition; chiral discrimination; noncovalent binding; molecular design; N-4-tetradentates; alpha-aminoacidates; asymmetric synthesis; DNA metallointercalators;

D O I：

10.1016/S0010-8545(97)00048-9

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Molecular design features which determine the enantio-and stereoselective behaviour of metal complexes derived from chiral linear N-4-tetradentate ligands with terminal alpha-pyridyl are described. Examples are provided of the ability of these complexes to recognise the molecular structures of biologically interesting molecules (alpha-aminoacids and nucleic acids). Noncovalent binding and steric factors which influence these molecular recognition processes are analysed and assessed. These include discriminatory interactions which occur at the intraligand, interligand (intramolecular) and intermolecular levels. (C) 1997 Elsevier Science S.A.

引用

页码：361 / 389

页数：29

共 112 条

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