Time course of inwardly rectifying K+ current reduction in glial cells surrounding ischemic brain lesions

被引：25

作者：

Köller, H ^{[1
]}

Schroeter, M ^{[1
]}

Jander, S ^{[1
]}

Stoll, G ^{[1
]}

Siebler, M ^{[1
]}

机构：

[1] Univ Dusseldorf, Dept Neurol, D-40225 Dusseldorf, Germany

来源：

BRAIN RESEARCH | 2000年 / 872卷 / 1-2期

关键词：

astrocytes; electrophysiology; middle cerebral artery occlusion; neuroglia; rat;

D O I：

10.1016/S0006-8993(00)02434-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

K+ currents of activated glial cells surrounding ischemic infarcts are investigated using acutely dissociated cells from the periinfarct area after permanent middle cerebral artery occlusion in rats. Inwardly rectifying K+ currents (K-1R) were markedly reduced in cells neighboring infarcts with maximal alteration at day 3 after infarct followed by a partial recovery. This reduction of glial K-1R currents may contribute to the functional disturbances in the periinfarct area. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：194 / 198

页数：5

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