mTOR's role in ageing: protein synthesis or autophagy?

被引：110

作者：

Hands, Sarah L. ^{[1
]}

Proud, Christopher G. ^{[2
]}

Wyttenbach, Andreas ^{[1
]}

机构：

[1] Univ Southampton, Sch Biol Sci, Southampton SO16 7PX, Hants, England

[2] Univ Southampton, Southampton Gen Hosp, Div Human Genet, Sch Biol Sci, Southampton SO16 6YD, Hants, England

来源：

AGING-US | 2009年 / 1卷 / 07期

基金：

英国生物技术与生命科学研究理事会; 英国医学研究理事会; 英国惠康基金;

关键词：

ageing; TOR; protein synthesis; autophagy; rapamycin; LIFE-SPAN EXTENSION; CHAPERONE-MEDIATED AUTOPHAGY; DROSOPHILA FAT-BODY; AGE-RELATED DECLINE; C-ELEGANS; CAENORHABDITIS-ELEGANS; CALORIE RESTRICTION; SIGNALING PATHWAY; HYDROGEN-PEROXIDE; MAMMALIAN TARGET;

D O I：

10.18632/aging.100070

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The molecular and cellular mechanisms that regulate ageing are currently under scrutiny because ageing is linked to many human diseases. The nutrient sensing TOR pathway is emerging as a key regulator of ageing. TOR signaling is complex affecting several crucial cellular functions and two such functions, which show clear effects on ageing, are protein synthesis and autophagy. In this article we discuss the relative importance of both these processes in ageing, identify how TOR regulates translation and autophagy and speculate on links between the TOR signaling network and ageing pathways.

引用

页码：586 / 597

页数：12

共 100 条

[1]

ALVERS AL, 2009, AGING CELL

[2]

ARMOUR SM, 2009, AGING, V1

[3] Reduced expression of the Caenorhabditis elegans p53 ortholog cep-1 results in increased longevity [J].

Arum, Oge ;

Johnson, Thomas E. .

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 2007, 62 (09) :951-959

[4] Hydrogen peroxide activates p70S6k signaling pathway [J].

Bae, GU ;

Seo, DW ;

Kwon, HK ;

Lee, HY ;

Hong, S ;

Lee, ZW ;

Ha, KS ;

Lee, HW ;

Han, JW .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (46) :32596-32602

[5]

Balasubramanian Sundaravadivel, 2009, Cardiovascular & Hematological Agents in Medicinal Chemistry, V7, P52

[6] Expression of dominant-negative Dmp53 in the adult fly brain inhibits insulin signaling [J].

Bauer, Johannes H. ;

Chang, Chengyi ;

Morris, Siti Nur Sarah ;

Hozier, Suzanne ;

Andersen, Sandra ;

Waitzman, Joshua S. ;

Helfand, Stephen L. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (33) :13355-13360

[7]

Bauer JH, 2009, AGING-US, V1, P38

[8] Aging ROS or TOR [J].

Blagosklonny, Mikhail V. .

CELL CYCLE, 2008, 7 (21) :3344-3354

[9] Growth and aging: a common molecular mechanism [J].

Blagosklonny, Mikhail V. ;

Hall, Michael N. .

AGING-US, 2009, 1 (04) :357-362

[10] Lipofuscin: Mechanisms of age-related accumulation and influence on cell function [J].

Brunk, UT ;

Terman, A .

FREE RADICAL BIOLOGY AND MEDICINE, 2002, 33 (05) :611-619

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