Synthesis and vasodilative activity of tanshinone IIA derivatives

被引：35

作者：

Bi, Yue-Feng ^{[1
,2
]}

Xu, Hai-Wei ^{[1
,2
,3
]}

Liu, Xiao-Qing ^{[1
]}

Zhang, Xiao-Juan ^{[1
]}

Wang, Zhen-Ji ^{[1
]}

Liu, Hong-Min ^{[1
,2
]}

机构：

[1] Zhengzhou Univ, Sch Pharmaceut Sci, Zhengzhou 450001, Peoples R China

[2] Zhengzhou Univ, New Drug Res & Dev Ctr, Zhengzhou 450001, Peoples R China

[3] Furen Sci & Technol Pharmaceut, Zhengzhou 450003, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2010年 / 20卷 / 16期

关键词：

Synthesis; Vasodilative activity; Tanshinone; SALVIA-MILTIORRHIZA; NITRIC-OXIDE; CELLS;

D O I：

10.1016/j.bmcl.2010.06.076

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

A series of 2,2'-(substituted methylene)bis-(1,6,6-trimethyl-6,7,8,9-tetrahydrophenanthro[1,2-b]furan-10,11-dione) derivatives were synthesized by the reaction of tanshinone IIA (D(1)) and aromatic aldehyde in the presence of p-TsOH. Bromination derivative of D(1) and hydrolysis product of cryptotanshinone (D(2)) were also prepared in this work. Vasodilation activity in vitro of them was valuated on the contractile response of vascular thoracic aorta smooth muscle from Wistar rats for the first time. Most of them exhibited a concentration-dependent inhibition on the contractile response of norepinephrine. (c) 2010 Elsevier Ltd. All rights reserved.

引用

页码：4892 / 4894

页数：3

共 14 条

[1]

Direct electrochemical measurement of nitric oxide in vascular endothelium [J].