Class switching and Myc translocation:: how does DNA break?

被引：17

作者：

Casali, P ^{[1
]}

Zan, H ^{[1
]}

机构：

[1] Univ Calif Irvine, Ctr Immunol, Irvine, CA 92697 USA

来源：

NATURE IMMUNOLOGY | 2004年 / 5卷 / 11期

关键词：

D O I：

10.1038/ni1104-1101

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Chromosomal translocations involving immunoglobulin switch regions are commonly thought to arise from aberrant AID-induced DNA lesions. New data, however, suggest AID does not initiate such lesions, but acts subsequently in the B cell transformation process.

引用

页码：1101 / 1103

页数：3

共 12 条

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