Urokinase receptor and integrin partnership: coordination of signaling for cell adhesion, migration and growth

被引:345
作者
Ossowski, L [1 ]
Aguirre-Ghiso, JA [1 ]
机构
[1] Mt Sinai Sch Med, Dept Med, Div Med Oncol, Rochelle Belfer Chemotherapy Fdn, New York, NY 11029 USA
关键词
D O I
10.1016/S0955-0674(00)00140-X
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Urokinase-type plasminogen activator receptor (uPAR) binds the urokinase-type plasminogen activator (uPA) and facilitates a proteolytic cascade focused at the cell surface, More recently, uPAR was recognized as a multifunctional protein that, through its interactions with integrins, initiates signaling events that alter cell adhesion, migration and proliferation. Results obtained recently have led to new insights into the structural aspects of uPAR interaction with integrins, provided a more detailed description of the signaling pathway they induce, and determined that uPAR signaling plays a role in cell migration and tumorigenicity.
引用
收藏
页码:613 / 620
页数:8
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